stem cell epigenetics
summary
Reproductive stem or 'germ' cells develop into eggs and sperm.
Healthy childhood development depends on the health of these first
cells but they are unique in many ways. During their growth, they
undergo a large scale rebuilding of their architecture so that a
new embryo may be formed. In this rebuilding, mistakes can be made,
with severe consequences for embryonic and childhood health. Our
group carries out research to learn how these mistakes are made and
how they may affect development before and after birth.
group leader(s)
Dr Jeff Mann
Stem Cell Epigenetics Group
Murdoch Childrens Research Institute
Royal Children's Hospital
Flemington Road
Parkville Victoria 3052
T +61 3 9936 6516
E jeff.mann@mcri.edu.au
group leader biography
current research projects
Project 1: Epigenetic reformatting in mouse germ cell
development
We are involved in a number of projects to determine the role of
RNA interference, histone variants, and candidate epigenetic
modifiers in epigenetic reformatting in germ cells. We use a broad
and sophisticated array of cellular and molecular techniques. One
of the foundations for our work involves the production of
genetically modified mice, for which all the work is performed in
our laboratory.
team members
- Julie Chan - RESEARCH ASSISTANT
- Deidre Mattiske - Research Officer
- Michelle Tang - Research Assistant
publications
- Ling KH., Brautigan PJ., Hahn CN., Daish T., Rayner JR., Cheah PS., Raison JM., Piltz S., Mann JR., Mattiske DM., Thomas PQ., Adelson DL., Scott HS. Deep sequencing analysis of the developing mouse brain reveals a novel microRNA. BMC GENOMICS 12 (2011) PubMed
- Mann JR., Mattiske DM. RNA interference in mammalian DNA methylation (1) (1) This review is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal's usual peer review process. Biochemistry and Cell Biology (2011) PubMed