research

Dr David Burgner

contact details

David Burgner Dr David Burgner
Susceptibility to Paediatric Infection (SPIn)
Murdoch Childrens Research Institute
Royal Children's Hospital
Flemington Road
Parkville Victoria 3052

T +61 3 9936 6530
E david.burgner@mcri.edu.au

biography

David Burgner is a clinician and scientist in paediatric infectious diseases. He trained in the UK and Australia and did his PhD on host genetics and severe malaria at the University of Oxford and in The Gambia, West Africa. His post-graduate training was at Great Ormond Street Hospital and St Mary's Hospital, Imperial College, London. From 2002-2010 he was the clinical lead for paediatric infectious diseases and refugee child health, Child and Adolescent Health Services, Western Australia and Associate Professor of Paediatrics at the University of Western Australia. He moved to Melbourne in 2010 and is currently based at MCRI and Monash Children's, Southern Health.

achievements

Royal Australasian College of Physicians Excellence in Mentorship: Academic and Research (2010)
NHMRC Clinical Career Development Fellowship (2010-13)
Australian Society for Infectious Diseases Frank Fenner Award for Advanced Research in Infectious Diseases (2008)
Raine Medical Research Foundation Research Prize (commended) (2006)
Royal Australasian College of Physicians Servier Staff Fellowship (2005)
Member of the Editorial Boards: PLoS ONE, Genes, Pediatric Infectious Diseases Journal, Infectious Diseases: Research and Treatment and Journal of Pediatric Infectious Diseases
Board Member World Society for Paediatric Infectious Diseases (2010-)
Committee Member, Australian and New Zealand Paediatric Infectious Diseases Group (2010-)
United States Patent Application 61/051,721 filed 9 May 2008 'Kawasaki Disease'. Co-inventor

research focus & interest

David's overall research interests focus on understanding the differential susceptibility and consequences to childhood infection and inflammation, particularly in preterm infants and young children. A particular interest is Kawasaki disease, a paediatric vasculitis that damages the coronary arteries. He is co-lead of a large international consortium investigating genetic factors in Kawasaki disease and is also involved in epidemiological, cardiovascular and immunological studies of Kawasaki disease in Australia and overseas. He is currently developing projects that investigate the broader role of childhood infection on chronic vascular inflammation and atherosclerosis.

tier 1 and 2 publications

Khor CC, Davila S, Breunis WB, Lee Y-C, Shimizu C, Wright VJ, Yeung RSM, Tan DEK, Kar KS, Wang JJ, Wong TY, Pang J, Paul Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park I-S, Lee J-K, Wu J-Y, Levin M‡, Burns JC‡, Burgner D‡, Kuijpers TW‡, Hibberd ML‡ on behalf of the Hong Kong-Shanghai, Korean, Taiwan, U.S. and International, Kawasaki Disease Genetics Consortiums. Genome-wide association study identifies FCGR2A as a susceptibility factor for Kawasaki disease. Nature Genetics ‡Joint senior and corresponding author 
Khor CC, Davila S, Shimizu, C, Sheng S, Matsubara T, Suzuki Y, Newburger JW, Baker A, Burgner D, Breunis W, Kuijpers TW, Wright VJ, Levin M, Hibberd ML, Burns JC, on behalf of US and International Kawasaki Disease Genetics Consortia.. Genome wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease. Journal of Medical Genetics. 2011;48(7):467-472.
Rye MS, Wiertsema SP, Scaman ES, Oommen J, Sun W, Francis RW, Ang W, Pennell CE, Burgner D, Richmond P, Vijayasekaran S, Coates HL, Brown SD, Blackwell JM, Jamieson SE. FBXO11, a regulator of the TGFbeta pathway, is associated with severe otitis media in Western Australian children. Genes Immun. 2011 Feb 3. [Epub ahead of print]
Currie AJ, Curtis S, Strunk T, Riley K, Liyanage K, Prescott S, Doherty D, Simmer K, Richmond P, Burgner D. Preterm infants have deficient monocyte and lymphocyte cytokine responses to group B streptococcus. Infect Immun. 2011;79(4):1588-96.
Yim D, Ramsay J, Kothari D, Burgner D. Coronary artery dilatation in toxic shock-like syndrome: the Kawasaki disease shock syndrome. Pediatr Cardiol. 2010;31:1232-1235.
Woodland L, Burgner D, Paxton G, Zwi K. Health service delivery for newly arrived refugee children: a framework for good practice. J Paediatr Child Health. 2010;46:560-567.
Rye MS, Bhutta MF, Cheeseman MT, Burgner D, Blackwell JM, Brown SD, Jamieson SE. Unraveling the genetics of otitis media: from mouse to human and back again. Mamm Genome. 2010;22:66-82.5
Murray RJ, Davis JS, Burgner DP, Hansen-Knarhoi M, Krause V, Biggs BA, Lemoh C, Benson J, Cherian S, Buttery J, Paxton G. The Australasian Society for Infectious Diseases guidelines for the diagnosis, management and prevention of infections in recently arrived refugees: an abridged outline. Med J Aust. 2009;190:421-425.
Harnden A, Takahashi M, Burgner D. Kawasaki disease. BMJ. 2009;338:b1514.
Harnden A, Mayon-White R, Perera R, Yeates D, Goldacre M, Burgner D. Kawasaki disease in England: ethnicity, deprivation, and respiratory pathogens. Pediatr Infect Dis J. 2009;28:21-24.
Blyth CC, Best EJ, Jones CA, Nourse C, Goldwater PN, Daley AJ, Burgner D, Henry G, Palasanthiran P. Nontuberculous mycobacterial infection in children: a prospective national study. Pediatr Infect Dis J. 2009;28:801-805.
Wright H, Waddington C, Geddes J, Newburger JW, Burgner D. Facial nerve palsy complicating Kawasaki disease. Pediatrics. 2008;122:e783-785.
Cherian S, Forbes D, Sanfilippo F, Cook A, Burgner D. The epidemiology of Helicobacter pylori infection in African refugee children resettled in Australia. Med J Aust. 2008;189:438-441.
Cherian S, Burgner D, Carson CF, Sanfilippo FM, Cook AG, Forbes DA. Diagnosis of Helicobacter pylori infection in a high-prevalence pediatric population: a comparison of 2 fecal antigen testing methods and serology. J Pediatr Gastroenterol Nutr. 2008;47:130-135.
Zwi K, Raman S, Burgner D, Faniran S, Voss L, Blick B, Osborn M, Borg C, Smith M. Towards better health for refugee children and young people in Australia and New Zealand: The Royal Australasian College of Physicians perspective. J Paediatr Child Health. 2007;43:522-526.
Moore H, Burgner D, Carville K, Jacoby P, Richmond P, Lehmann D. Diverging trends for lower respiratory infections in non-Aboriginal and Aboriginal children. J Paediatr Child Health. 2007;43:451-457.
Carville KS, Lehmann D, Hall G, Moore H, Richmond P, de Klerk N, Burgner D. Infection is the major component of the disease burden in aboriginal and non-aboriginal Australian children: a population-based study. Pediatr Infect Dis J. 2007;26:210-216.
Peadon E, Burgner D, Nissen M, Buttery J, Zurynski Y, Elliott E, Gold M, Marshall H, Booy R. Case for varicella surveillance in Australia. J Paediatr Child Health. 2006;42:663-664.
Munns C, Zacharin MR, Rodda CP, Batch JA, Morley R, Cranswick NE, Craig ME, Cutfield WS, Hofman PL, Taylor BJ, Grover SR, Pasco JA, Burgner D, Cowell CT. Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement. Med J Aust. 2006;185:268-272.
Lee KY, Lee HS, Hong JH, Lee MH, Lee JS, Burgner D, Lee BC. Role of prednisolone treatment in severe Mycoplasma pneumoniae pneumonia in children. Pediatr Pulmonol. 2006;41:263-268.
Lee KY, Hong JH, Han JW, Lee JS, Lee BC, Burgner D. Features of Kawasaki disease at the extremes of age. J Paediatr Child Health. 2006;42:423-427.
Burgner D, Jamieson SE, Blackwell JM. Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better? Lancet Infect Dis. 2006;6:653-663.