BRACE COVID-19-Specific vaccine sub-study (BCOS)
With philanthropic support from the Bill & Melinda Gates Foundation, this is a sub-study to the Murdoch Children’s Research Institute’s trial of BCG vaccine to reduce the impact of COVID-19. By recruiting existing BRACE trial participants to the sub-study, researchers are seeking answers to these key questions:
BCOS Australia and BrazilDoes BCG vaccination, by boosting the immune system, improve the response to Pfizer, AstraZeneca and CoronaVac?
BCOS BrazilIs it possible to predict who remains susceptible to SARS-CoV-2 variants despite previous COVID-19 disease or COVID-19-specific vaccination?
Calling for participants in Victoria and South Australia
The BRACE study team is seeking participants to enrol in the sub-study if you:
- Are a participant in the BRACE trial
- Are a healthcare worker at the Royal Children’s Hospital, Melbourne, Epworth HealthCare, Women's and Chilren's Hospital, Adelaide or the Royal Adelaide Hospital
- Have not yet had a COVID-19-specific vaccine
- Have not previously been diagnosed with COVID-19
What to expect
To participate in BCOS, you simply need to attend one, two or three vaccine sub-study clinic visits and provide a blood sample each time. The number of visits depends on the type of COVID-19-specific vaccine you receive. Where possible, these will be combined with your regular BRACE trial 3-monthly clinic visit.
You also need to complete additional questionnaires a week after each vaccine sub-study clinic visit to tell us which COVID-19-specific vaccine you have been given and any reactions you experience.
Your participation in the sub-study will end 28 days after you receive your second dose of COVID-19-specific vaccine.
Learn more about BCOS
MCRI’s BCG vaccine trial joins global race to better understand COVID-19 variants. will also look at whether BCG vaccine improves the immune response to Pfizer, AstraZeneca and CoronaVac vaccines.
The global race to understand Covid-19 variants
Is it possible to predict who’s susceptible to SARS-CoV-2 variants – despite previous COVID-19 infection or vaccination?
ABC NewsRadio interview
Dr Nicole Messina, BRACE Biosample and Laboratory Lead, speaks on ABC NewsRadio about the BRACE COVID-19-Specific vaccine sub-study.