The Heart Regeneration Group studies the molecular and cellular mechanisms that govern heart development and regeneration. We are focused on the development of novel regenerative therapies for congenital and acquired forms of heart disease based on a deep understanding of developmental biology. Our laboratory employs a range of cutting edge technologies including patient-matched stem cells, genome editing, genomic sequencing and animal models to identify new drug targets for heart regeneration. We are working closely with clinicians and scientists both nationally and across the Melbourne Children’s precinct to foster knowledge transfer and translation of research discoveries from bench to bedside.
Post-natal control of cardiac gene regulatory networks
Epigenetic modifications are critical for the precise temporal regulation of gene expression during heart development. We are trying to map the changes in the genomic landscape during post-natal heart development to identify the molecular drivers of cardiac regeneration during early developmental stages.
Modelling human heart development using human cardiac organoids
Recent advances in stem cell sciences and tissue engineering are providing unparalleled opportunities to generate human heart tissues in a dish. We are using human cardiac organoids to understand the mechanisms that regulate the developmental maturation of human heart muscle.
Functional genomic screens for cardiovascular drug discovery
We are also applying unbiased screening approaches to identify novel therapeutic candidates for cardiac regeneration in human cardiac organoids.
- Differential Response to Injury in Fetal and Adolescent Sheep Hearts in the Immediate Post-myocardial Infarction Period. 2019
- Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway. 2019
- Programmable Nuclease-Based Integration into Novel Extragenic Genomic Safe Harbor Identified from Korean Population-Based CNV Analysis. 2019
- Stage-dependent cardiac regeneration in Xenopus is regulated by thyroid hormone availability. 2019
- Stem cell topography splits growth and homeostatic functions in the fish gill. 2019
- 3D aggregate culture improves metabolic maturation of human pluripotent stem cell derived cardiomyocytes. 2018
- A symphony of stem cells in Vienna - looking to the future. 2018
- Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model. 2018
- Isolation and characterization of ventricular-like cells derived from NKX2-5eGFP/wand MLC2vmCherry/wdouble knock-in human pluripotent stem cells. 2018
- NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. 2018
- Paediatric anthracycline-induced cardiotoxicity: mechanisms, pharmacogenomics and pluripotent stem cell modelling. 2018
- Systematic review of pharmacogenomics and adverse drug reactions in paediatric oncology patients. 2018
- TrawlerWeb: an online de novo motif discovery tool for next-generation sequencing datasets. 2018
- Biomarkers of Human Pluripotent Stem Cell-Derived Cardiac Lineages. 2017
- Chemotherapy-related cardiotoxicity: are Australian practitioners missing the point? 2017
- Development of a human cardiac organoid injury model reveals innate regenerative potential. 2017
- Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. 2017
- FunSel: Mesenchymal Stromal Cells Stay for the Party. 2017
- Multicellular Transcriptional Analysis of Mammalian Heart Regeneration. 2017
- Neural stem cells induce the formation of their physical niche during organogenesis. 2017
- Dr James Hudson, The University of Queensland
- Dr David Elliott, Murdoch Children's Research Institute
- Prof Igor Konstantinov, Royal Children’s Hospital
- Prof Assam El-Osta, Monash University
- Dr Paul Gregorevic, Baker Heart Research Institute
- A/Prof Mathias Francois, Institute for Molecular Bioscience, UQ