Australian parent-child concordance values for the microvasculature align with moderate polygenic heritability reported in smaller studies.
- Dascalu J, Liu M, Lycett K, Grobler AC, He M, Burgner DP, Wong TY, Wake M. Retinal microvasculature: Population epidemiology and concordance in Australian children aged 11-12 years and their parents. BMJ Open 2019;9(suppl 3):44–52. doi: 10.1136/bmjopen-2018-022399
In childhood, emerging relationships between microvascular parameters and cardiometabolic risk may be better described by retinal vascular caliber than by geometric parameters.
- Liu M, Lycett K, Wake M, He M, Kerr JA, R Saffery, et al. Cardiovascular health and retinal microvascular geometry in Australian 11–12 year-olds. Microvascular Research. 2020; 129, 103966. DOI: 10.1016/j.mvr.2019.103966
Adverse retinal microvascular characteristics are associated with hearing loss by midlife, with venular associations possibly emerging by age 11 to 12 years.
- Wang J, Liu M, Sung V, Lycett K, Grobler A, Burgner D, et al. Associations of Retinal Vessel Caliber With Hearing Status in Childhood and Midlife: A Cross-Generational Population-Based Study. JAMA Otolaryngology - Head & Neck Surgery. 2020. DOI: 10.1001/jamaoto.2019.4484
Inflammation mediated associations between obesity and retinal venules, but not arterioles from mid-childhood, with higher mediation effects observed in adults.
- Liu M, Lycett K, Moreno-Betancur M, Wong TY, He M, Saffery R, et al. Inflammation mediates the relationship between obesity and retinal vascular calibre in children and mid-life adults. Scientific Reports. 2020; 10, 5006. DOI: 10.1038/s41598-020-61801-w