Australian parent-child concordance values for the microvasculature align with moderate polygenic heritability reported in smaller studies.
- Dascalu J, Liu M, Lycett K, Grobler AC, He M, Burgner DP, Wong TY, Wake M. Retinal microvasculature: Population epidemiology and concordance in Australian children aged 11-12 years and their parents. BMJ Open 2019;9(suppl 3):44–52. doi: 10.1136/bmjopen-2018-022399
In childhood, emerging relationships between microvascular parameters and cardiometabolic risk may be better described by retinal vascular caliber than by geometric parameters.
- Liu M, Lycett K, Wake M, He M, Kerr JA, R Saffery, et al. Cardiovascular health and retinal microvascular geometry in Australian 11–12 year-olds. Microvascular Research. 2020; 129, 103966. DOI: 10.1016/j.mvr.2019.103966
Adverse retinal microvascular characteristics are associated with hearing loss by midlife, with venular associations possibly emerging by age 11 to 12 years.
- Wang J, Liu M, Sung V, Lycett K, Grobler A, Burgner D, et al. Associations of Retinal Vessel Caliber With Hearing Status in Childhood and Midlife: A Cross-Generational Population-Based Study. JAMA Otolaryngology - Head & Neck Surgery. 2020. DOI: 10.1001/jamaoto.2019.4484
Inflammation mediated associations between obesity and retinal venules, but not arterioles from mid-childhood, with higher mediation effects observed in adults.
- Liu M, Lycett K, Moreno-Betancur M, Wong TY, He M, Saffery R, et al. Inflammation mediates the relationship between obesity and retinal vascular calibre in children and mid-life adults. Scientific Reports. 2020; 10, 5006. DOI: 10.1038/s41598-020-61801-w
A high body mass index or a large waist in early childhood impacts on the retinal microvasculature by 11-12 years of age, more via arteriolar than venular mechanisms.
- Liu M, Lycett K, Wong TY, Kerr JA, He M, Juonala M, et al. Do body mass index and waist-to-height ratio over the preceding decade predict retinal microvasculature in 11–12 year olds and midlife adults? International Journal of Obesity. 2020. DOI: 10.1038/s41366-020-0584-9
In children and midlife adults, we found that narrower retinal arterioles and wider venules are associated with large arterial function as early as mid-childhood, with associations strengthen by mid-life and also extend to arterial structure.
Liu M, Lycett K, Wong T, Juonala M, He M, Dwyer T, et al. Associations of retinal microvascular caliber with large arterial function and structure: A population-based study of 11-12 year-olds and mid-life adults. Microcirculation. DOI: 10.1111/micc.12642