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Young Bloods

In midlife adults, but not children, there was some evidence that telomere length was associated with vascular elasticity but not thickness.

A novel biomarker of chronic inflammation, GlycA, is associated with poorer hearing by childhood. This potentially reframes hearing loss as a life-course condition with inflammatory antecedents common to other non-communicable diseases.

Telomere length was not associated with hearing acuity in children or their midlife parents.

This systematic review found that baseline health and nutritional status of the pregnant mother seems to play a pivotal role in response to gestational nutritional supplementation, on DNA methylation fluctuations in neonatal tissues.

The piece outlines the roadmap to advancing nutritional public health research by validating biomarkers of nutritional status, such as metabolomics profiles.

This paper provides an overview of how machine learning is positioned to improve polygenic risk scoring, towards the goal of better precision medicine.

We measured 70 circulating metabolites in the blood, and found no associations in children and parents with cIMT (a measure of cardiovascular structure). There were some signals that glucose and HDL cholesterol were associated with pulse wave velocity in parents.

We report distinct age- and sex-specific metabolic profiles, with concentrations and sex differences generally greater in adults than children.

Albuminuria is common among Australian children and adults, which is of concern because it predicts risk for kidney and cardiovascular disease and mortality.

Relative telomere length is shorter in adults than children, and modest parent-child concordance diminishes with increasing parent age.

Adverse sleep characteristics may play a limited role in shortening of telomeres in generally healthy populations up to at least midlife.

Shorter telomere length showed moderate associations with poorer airflow parameters, but not vital capacity (lung volume) in mid‐life adults. However, there was no convincing evidence of associations in children. 

Cuff-based XSP associates with carotid IMT independent of conventional risk factors, including traditional BP, but the association was weak, indicating that further investigation is warranted to understand the clinical significance of reservoir pressure parameters.

Inflammation mediated associations between obesity and retinal venules, but not arterioles from mid-childhood, with higher mediation effects observed in adults.

Better child and adult mental health were associated with cardio-protective blood metabolite profiles, including lower levels of inflammatory markers and a favourable lipid/lipoprotein profile.

Age, sex, and shared family factors, including diet, contribute to variation in plasma concentrations of TMAO and its precursors in the Growing Up in Australia’s Child Health Checkpoint.

Frequent takeaway food, and to a lesser degree sugar-sweetened beverage consumption, is associated with adverse preclinical cardiovascular phenotypes in adults. Lack of such associations in children highlights opportunities for prevention of disease.

Evidence of a link between adversity and chronic inflammation in both mid and late childhood was found by using data from two cohorts (Barwon Infant Study and the Longitudinal Study of Australian Children Child Health CheckPoint) that capture different age ranges. 

Age, sex, and shared familial factors are important determinants of plasma amino acid concentrations in Australian children and adults.

Family, age, and sex contribute to variations in the concentrations of plasma B vitamers in Australian children and adults.