In midlife adults, but not children, there was some evidence that telomere length was associated with vascular elasticity but not thickness.
- Nguyen MT, R Vryer, S Ranganathan, K Lycett, A Grobler, T Dwyer, et al. Telomere length and vascular phenotypes in a population-based cohort of children and midlife adults. Journal of the American Heart Association, 2019. 8(11): p. e012707. DOI: 10.1161/JAHA.119.012707
A novel biomarker of chronic inflammation, GlycA, is associated with poorer hearing by childhood. This potentially reframes hearing loss as a life-course condition with inflammatory antecedents common to other non-communicable diseases.
- Wang J, Liu RS, Sung V, Burgner D, Carew P, et al. Inflammation and hearing status in mid-childhood and mid-life: a population-based cross-sectional study. International Journal of Epidemiology, 2019. DOI: 10.1093/ije/dyz023.
Telomere length was not associated with hearing acuity in children or their midlife parents.
- Wang J, Nguyen MT, Sung V, Grobler A, Burgner D, et al., Associations between telomere length and hearing status in mid-childhood and midlife: Population-based cross-sectional study. Ear and Hearing, 2019. DOI: 10.1097/aud.0000000000000705
This systematic review found that baseline health and nutritional status of the pregnant mother seems to play a pivotal role in response to gestational nutritional supplementation, on DNA methylation fluctuations in neonatal tissues.
- Andraos S, de Seymour JV, O’Sullivan JM, Kussmann M. The impact of nutritional interventions in pregnant women on DNA methylation patterns of the offspring: A systematic review. Molecular Nutrition & Food Research, 2018. 62(24): p. e1800034. DOI:10.1002/mnfr.201800034
The piece outlines the roadmap to advancing nutritional public health research by validating biomarkers of nutritional status, such as metabolomics profiles.
- Andraos S, Wake M, Saffery R, Burgner D, Kussmann M, O'Sullivan J. Perspective: Advancing understanding of population nutrient-health relations via metabolomics and precision phenotypes. Advances in Nutrition, 2019. p. nmz045. DOI: 10.1093/advances/nmz045
This paper provides an overview of how machine learning is positioned to improve polygenic risk scoring, towards the goal of better precision medicine.
- Ho DSW, Schierding W, Wake M, Saffery R, O’Sullivan JM. Machine learning SNP based predictions for precision medicine. Frontiers in Genetics. DOI: 10.3389/fgene.2019.00267.
We measured 70 circulating metabolites in the blood, and found no associations in children and parents with cIMT (a measure of cardiovascular structure). There were some signals that glucose and HDL cholesterol were associated with pulse wave velocity in parents.
- Juonala M, Ellul S, Lawlor DA, Santos Ferreira DL, Carlin JB, Cheung M, et al. A Cross-Cohort Study Examining the Associations of Metabolomic Profile and Subclinical Atherosclerosis in Children and Their Parents: The Child Health CheckPoint Study and Avon Longitudinal Study of Parents and Children. Journal of the American Heart Association. 2019;8:e011852. DOI:10.1161/JAHA.118.011852.
We report distinct age- and sex-specific metabolic profiles, with concentrations and sex differences generally greater in adults than children.
- Ellul S, Wake M, Clifford SA, Lange K, Wurtz P, Juonala M, et al. Metabolomics: population epidemiology and concordance in Australian children aged 11-12 years and their parents.BMJ Open. 2019. 9(Suppl 3): p. 106-117. DOI: 10.1136/bmjopen-2017-020900.
Albuminuria is common among Australian children and adults, which is of concern because it predicts risk for kidney and cardiovascular disease and mortality.
- Larkins NG, Kim S, Carlin JB, Grobler AC, Burgner DP, Lange K, et al. Albuminuria: population epidemiology and concordance in Australian children aged 11-12 years and their parents.BMJ Open. 2019. 9(Suppl 3): p. 75-84. DOI: 10.1136/bmjopen-2017-020262.
Relative telomere length is shorter in adults than children, and modest parent-child concordance diminishes with increasing parent age.
- Nguyen MT, Lycett K, Vryer R, Burgner DP, Ranganathan S, Grobler AC, et al. Telomere length: population epidemiology and concordance in Australian children aged 11-12 years and their parents. BMJ Open. 2019. 9(Suppl 3): p. 118-126. DOI: 10.1136/bmjopen-2017-020263.
Adverse sleep characteristics may play a limited role in shortening of telomeres in generally healthy populations up to at least midlife.
- Nguyen MT, Lycett K, Olds T, Matricciani L, Vryer R, Ranganathan S, et al. Objectively measured sleep and telomere length in a population-based cohort of children and midlife adults. Sleep.2019; pii: zsz200. DOI: 10.1093/sleep/zsz20
Shorter telomere length showed moderate associations with poorer airflow parameters, but not vital capacity (lung volume) in mid‐life adults. However, there was no convincing evidence of associations in children.
- Nguyen MT, Saffery R, Burgner D, Lycett K, Vryer R, Grobler A, et al. Telomere length and lung function in a population-based cohort of children and mid-life adults. Pediatric Pulmonology.2019;54(12): 2044-2052. DOI: 10.1002/ppul.24489.
Cuff-based XSP associates with carotid IMT independent of conventional risk factors, including traditional BP, but the association was weak, indicating that further investigation is warranted to understand the clinical significance of reservoir pressure parameters.
- Peng X, Wake M, Schultz MG, Burgner DP, Otahal P, Mynard J, et al. Association of brachial-cuff excess pressure with carotid intima-media thickness in Australian adults: a cross-sectional study. Journal of Hypertension. 2020;38(4):723-730.
Inflammation mediated associations between obesity and retinal venules, but not arterioles from mid-childhood, with higher mediation effects observed in adults.
- Liu M, Lycett K, Moreno-Betancur M, Wong TY, He M, Saffery R, et al. Inflammation mediates the relationship between obesity and retinal vascular calibre in children and mid-life adults. Scientific Reports. 2020; 10, 5006. DOI: 10.1038/s41598-020-61801-w
Better child and adult mental health were associated with cardio-protective blood metabolite profiles, including lower levels of inflammatory markers and a favourable lipid/lipoprotein profile.
- Lange K, Lycett K, Ellul S, Saffery R, Mensah F, Carlin J, et al. Cross-sectional metabolic profiles of mental health in population-based cohorts of 11- to 12-year-olds and mid-life adults: The Longitudinal Study of Australian Children. Australian & New Zealand Journal of Psychiatry. 2020. DOI: 10.1177/0004867420924092.
Age, sex, and shared family factors, including diet, contribute to variation in plasma concentrations of TMAO and its precursors in the Growing Up in Australia’s Child Health Checkpoint.
- Andraos S, Lange K, Clifford SA, Jones B, Thorstensen EB, Kerr JA, et al. Plasma Trimethylamine N-Oxide and Its Precursors: Population Epidemiology, Parent–Child Concordance, and Associations with Reported Dietary Intake in 11- to 12-Year-Old Children and Their Parents, Current Developments in Nutrition, Volume 4, Issue 7, July 2020, nzaa103, https://doi.org/10.1093/cdn/nzaa103
Frequent takeaway food, and to a lesser degree sugar-sweetened beverage consumption, is associated with adverse preclinical cardiovascular phenotypes in adults. Lack of such associations in children highlights opportunities for prevention of disease.
- Saraf S, Grobler A, Liu RS, Liu M, Wake M, Olds T, et al. Takeaway food, sugar-sweetened beverages and preclinical cardiometabolic phenotypes in children and adults. European Journal of Preventive Cardiology, 2020. zwaa070, https://doi.org/10.1093/eurjpc/zwaa070
Evidence of a link between adversity and chronic inflammation in both mid and late childhood was found by using data from two cohorts (Barwon Infant Study and the Longitudinal Study of Australian Children Child Health CheckPoint) that capture different age ranges.
- O'Connor M, Ponsonby AL, Collier F, Liu R, D.Sly P, Azzopardi P, et al. Exposure to adversity and inflammatory outcomes in mid and late childhood. Brain, Behavior, & Immunity. 2020. https://doi.org/10.1016/j.bbih.2020.100146
Age, sex, and shared familial factors are important determinants of plasma amino acid concentrations in Australian children and adults.
- Andraos S, Lange K, Clifford SA, Jones B, Thorstensen EB, Wake M, et al. Population epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents. Sci Rep 11, 3619 (2021). https://doi.org/10.1038/s41598-020-80923-
Family, age, and sex contribute to variations in the concentrations of plasma B vitamers in Australian children and adults.
- Andraos S, Jones B, Wall C, Thorstensen E, Kussmann M, Smith D-C, et al. Plasma B Vitamers: Population Epidemiology and Parent-Child Concordance in Children and Adults. Nutrients 2021, 13, 821. https://doi.org/10.3390/nu13030821