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Heart Lab

Children from poorer families have worse cardiovascular health by mid-childhood.

Carotid intima-media thickness (cIMT) is an increasingly common marker of cardiovascular risk measured in population health studies. Thickness varies up to 14% across the cardiac cycle, so future studies should measure cIMT at the same point in the cardiac cycle to aid comparison between studies.

Lower Ideal Cardiovascular Health scores were associated with adverse adult vascular phenotypes and adverse child vascular function.

In midlife adults, but not children, there was some evidence that telomere length was associated with vascular elasticity but not thickness.

We measured 70 circulating metabolites in the blood, and found no associations in children and parents with cIMT (a measure of cardiovascular structure). There were some signals that glucose and HDL cholesterol were associated with pulse wave velocity in parents.

An inflammatory diet is associated with adverse cardiovascular function and microvascular structure in parents but not children.

In midlife adults, but not children, there was some evidence that telomere length was associated with vascular elasticity but not thickness.

Cross-generational concordance in multiple vascular function markers is established early.

Australian parent-child concordance values for the microvasculature align with moderate polygenic heritability reported in smaller studies.

Cuff-based XSP associates with carotid IMT independent of conventional risk factors, including traditional BP, but the association was weak, indicating that further investigation is warranted to understand the clinical significance of reservoir pressure parameters.

In children and midlife adults, we found that narrower retinal arterioles and wider venules are associated with large arterial function as early as mid-childhood, with associations strengthen by mid-life and also extend to arterial structure.