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The MIST Trial

What is MIST?

Snoring and difficulty breathing while asleep is very common in childhood and can cause lots of sleepless nights, as well as behaviour and concentration problems during the day.    

Up to now, the main treatment for snoring and difficulty breathing in sleep is surgery. We want to see if a nose spray (mometasone) can help children sleep better and avoid surgery.  This medicine is already commonly used in children with hay fever and is available over the counter (without a prescription). 

Who can take part?

Families with children:

  • aged 3-12 years
  • who snore most nights and have some difficulty during sleep

Who can’t take part?

Children who:

  • have already had their tonsils removed
  • have a serious long-term health problem  

What will I be asked to do?

  • Attend 2 visits at either Monash Health or the Royal Children’s hospital, 6 weeks apart
  • Give your child nose spray of the active medicine or placebo (saline) every day, for 6 weeks
  • Complete 4 short surveys over the next 2 years. 

How can I find out more?

If you have any questions about the study, please contact Dr Alice Baker at 03 9936 6543 or

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