The MIST Trial

What is MIST?

Snoring and difficulty breathing while asleep is very common in childhood.  This can lead to poor quality sleep, which can impact the child’s behaviour and concentration during the day, and the whole family’s quality of life.  

Up to now, the main treatment for snoring and difficulty breathing in sleep is surgery. We are researching a new less invasive treatment– a nasal spray (mometasone).  This medicine is already commonly used in children with hay fever and is available over the counter (without a prescription). We want to see if this can reduce difficulty breathing and improve sleep, and reduce the need for surgery.  

Who can take part?

Families with children:

  • aged 3-12 years
  • who snore most nights and have some difficulty during sleep

Who can’t take part?

Children who:

  • have already had their tonsils removed
  • have a serious long-term health problem  

What will I be asked to do?

  • Attend 2 visits at either Monash Health or the Royal Children’s hospital, 6 weeks apart
  • Give your child nasal spray of the active medicine or placebo (saline) every day, for 6 weeks
  • Complete 4 surveys over the next 2 years.  

How can I find out more?

If you have any questions about the study, please contact Dr Alice Baker at 03 9936 6543 or  

Click here to register your interest.