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Study of BCG-vaccinated adult blood

The Cellular Immunology group at the MCRI is seeking healthy adult volunteers to donate blood.

We are investigating immune cells in individuals who have received the BCG vaccine (the vaccine for TB), compared to those who have not received this vaccine.

We require blood samples from healthy adults (aged 18-80) who:  

  • Have received the BCG vaccine (ever), or
  • Have not received the BCG vaccine

There will be a short screening questionnaire based on the same eligibility criteria as the Red Cross, which will include questions about your recent health. A copy of the questionnaire can be obtained prior to participation.

If you are interested in volunteering for this study, please contact Scott in the Cellular Immunology group at


Project outline and information

What is the research project about?

This project is about studying white blood cells in people who have received the Bacillus Calmette-Guérin (BCG) vaccine (the vaccine for tuberculosis), and comparing them to white blood cells from people who have not received the BCG vaccine.

Who is running the project?

This project is being run by researchers in the Cellular Immunology group at the Murdoch Children's Research Institute (MCRI), located at the Royal Children's Hospital (RCH).

Funding for this work is provided by the National Health and Medical Research Council, which is Australia's peak funding body for medical research.

Why am I being asked to take part?

If you meet the criteria for inclusion in this study after completing the attached questionnaire, you may be asked for a blood sample. Broadly speaking, donors for this study must be healthy adults with a known BCG vaccination status.

What do I need to do in this research project?

This project will only require a single blood donation, following completion of the screening questionnaire.

The questions in this questionnaire (excluding those that specifically discuss BCG or factors that may impact results), are modified from the screening questionnaire for blood donations to the Australian Red Cross. These questions are asked to ensure both your safety and the safety of researchers.

What are the possible benefits for me and other people in the future?

This project aims to better understand how we might treat and prevent tuberculosis.

What are the possible risks, side-effects, discomforts and/or inconveniences?

As your involvement in this project is a once-off blood draw, there are no risks/side effects/discomforts/inconveniences outside of what you would experience from having a blood sample taken. These are outlined in 'Information about blood collection'.

What will be done to make sure my information is confidential?

This project will only study the white blood cells from your sample. To keep your information private, your sample will be 'de-identified' - there will be no information kept with your sample that can be used to personally identify you. The answers you provide on the questionnaire will never be linked back to you - they are screening questions designed to determine your eligibility, to make sure that it is safe for you to participate, and to make sure researchers processing your sample will be safe. RCH and MCRI are research partners – this means that the two organisations will always share research information with each other.

Who should I contact for more information?

If you would like more information about the project, including any queries about anything in this document (including the questionnaire), please contact the lead investigator on this project:

Name: Dr Daniel Pellicci


Subject: "Questions about BCG vaccine project at MCRI"

You can also contact Research Ethics & Governance at The Royal Children's Hospital Melbourne if you:

  • have any concerns or complaints about the project
  • are worried about your rights as a research participant
  • would like to speak to someone independent of the project.