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Projects

Research project
The Vaccine & Immunisation Research Group of the Murdoch Children’s Research Institute at The Royal Children’s Hospital and The University of Melbourne is conducting a research study on an investigational vaccine against pneumococcal infections in infants. What is Pneumococcal disease? Pneumococcal disease is caused by a type of bacterium called Streptococcus pneumoniae. This bacterium is a major cause of infection that may be in the ears, sinuses, blood, lungs or brain. There is already a licensed vaccine which protects against pneumococcal disease and this is being used to compare to the study vaccine. What is the study about? The purpose of this study is to compare the study vaccine with a currently licensed vaccine to study its safety, how well it is tolerated, and how well your child responds to the investigational vaccine. Who can participate? Participants must: Be aged between 6 to 12 weeks of age Not have received ...
Research project
Murdoch Children’s Research Institute awarded $10M to lead a global program to wipe out the scabies parasite. What is scabies? Scabies is a skin disease caused by a tiny mite (Sarcoptes scabiei) that burrows under the skin and lays its eggs, resulting in traumatic itching – an irritation so severe people cannot sleep and may scratch themselves until they bleed. What happens to people with scabies? Constant scratching caused by the mites opens up the skin, leading to bacterial skin infections and that in severe cases blood poisoning, kidney failure and heart disease. Who does it effect? Globally, there are an estimated 455 million cases of scabies every year, and around million people are affected at any time. Mites thrive in hot, crowded conditions – schools, villages, refugee camps and prisons – and can be widespread in some low-income communities, including in remote communities in northern Australia, and parts of ...
Research project
The Vaccine & Immunisation Research Group of the Murdoch Childrens Research Institute in collaboration with The University of Melbourne is conducting a research study on a vaccine against meningococcal type A,C,W,Y infections in healthy adults between 18 and 40 years. What is meningococcal disease? Neisseria meningitidis or meningococcus is a family of germs (bacteria) that can cause meningitis, which is an infection of the surface of the brain. While meningitis is a rare infection, it can be life-threatening and lead to permanent disability. These bacteria can also cause an infection of the blood, called sepsis. The most common groups in the meningococcus family that can cause disease are groups A, B, C, W and Y. What is the study about? This study is comparing the body’s ability to produce antibodies against the study vaccines, as well as the safety of a new liquid formulation of the MenACWY vaccine with a ...
Research project
What is RSV? Respiratory Syncytial Virus (RSV) is a common virus that can cause serious respiratory illness in infants and young children. It is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia in infants and young children, which can result in hospitalisation. Preterm infants are at particularly high risk of hospitalisation with an RSV infection. There are no vaccines available to prevent RSV infection. Currently there is a medication to prevent RSV, but it is usually reserved for infants who have serious heart or lung disease, and some premature infants born at less than 28 weeks gestation. Purpose of the study This study is being done to evaluate how effective a new medication (called MEDI8897) is at preventing serious respiratory illness caused by RSV in preterm infants. Who can take part? Healthy infants who were born preterm at 29 to 35 weeks ...