Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute (MCRI). Prof Elefanty's research focuses on the differentiation of human pluripotent stem cells to understand and model blood diseases in vitro and for transplantation. Together with the laboratories of Professor Ed Stanley (Immune Development group) and Dr Elizabeth Ng (Blood Development group) at MCRI, Prof Elefanty has made important contributions to the generation of genetically modified human stem cell lines in which lineage-specific fluorescent reporters allow monitoring of differentiation.
After training as a physician, Professor Elefanty completed a PhD in leukaemogenesis at the Walter and Eliza Hall Institute of Medical Research supervised by Professor Suzanne Cory. He subsequently worked on globin gene regulation with Professor Frank Grosveld at the National Institute for Medical Research in Mill Hill, London before returning to the Hall Institute to pursue interests in developmental haematopoiesis and the differentiation of mouse embryonic stem cells.
He moved to Monash University in 2002 to initiate studies with human embryonic stem cells. In 2013, his laboratory relocated to the Murdoch Children’s Research Institute. In collaboration with Dr Elizabeth Ng and Prof Ed Stanley, he has focused on haematopoietic differentiation of human pluripotent stem cells.
Professor Elefanty holds active collaborations with:
• Professor Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Dr Elizabeth Ng, Blood Development Laboratory, Murdoch Children's Research Institute
• Professor Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Professor Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute (MCRI). Prof Elefanty's research focuses on the differentiation of human pluripotent stem cells to understand and model...
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute (MCRI). Prof Elefanty's research focuses on the differentiation of human pluripotent stem cells to understand and model blood diseases in vitro and for transplantation. Together with the laboratories of Professor Ed Stanley (Immune Development group) and Dr Elizabeth Ng (Blood Development group) at MCRI, Prof Elefanty has made important contributions to the generation of genetically modified human stem cell lines in which lineage-specific fluorescent reporters allow monitoring of differentiation.
After training as a physician, Professor Elefanty completed a PhD in leukaemogenesis at the Walter and Eliza Hall Institute of Medical Research supervised by Professor Suzanne Cory. He subsequently worked on globin gene regulation with Professor Frank Grosveld at the National Institute for Medical Research in Mill Hill, London before returning to the Hall Institute to pursue interests in developmental haematopoiesis and the differentiation of mouse embryonic stem cells.
He moved to Monash University in 2002 to initiate studies with human embryonic stem cells. In 2013, his laboratory relocated to the Murdoch Children’s Research Institute. In collaboration with Dr Elizabeth Ng and Prof Ed Stanley, he has focused on haematopoietic differentiation of human pluripotent stem cells.
Professor Elefanty holds active collaborations with:
• Professor Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Dr Elizabeth Ng, Blood Development Laboratory, Murdoch Children's Research Institute
• Professor Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Professor Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Top Publications
Tan, G, Elefanty, AG, Stanley, EG.
β-cell regeneration and differentiation: how close are we to the 'holy grail'?.
J Mol Endocrinol
53(3)
:
R119 -R129
2014
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Cao, J, Ng, ES, McNaughton, D, Stanley, EG, Elefanty, AG, Tobin, MJ, Heraud, P.
Fourier transform infrared microspectroscopy reveals unique phenotypes for human embryonic and induced pluripotent stem cell lines and their progeny..
J Biophotonics
7(10)
:
767 -781
2014
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Real, P, Menendez, P, Navarro-Montero, O, Ramos-Mejia, V, Ayllon, V, Elefanty, A, Bueno, C, Romero-Moya, D, Montes, R.
RUNX1c regulates hematopoietic specification of human embryonic stem cells.
Experimental Hematology
42(8)
:
s16
2014
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Andrea, D, Sturgeon, C, Awong, G, Kennedy, M, Ng, E, Stanley, E, Elefanty, A, Keller, G.
Declined Presentation Human definitive hemogenic endothelium represents a distinct lineage from arterial vascular endothelium.
Experimental Hematology
42(8)
:
s23
2014
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Skelton, RJP, Costa, M, Anderson, DJ, Bruveris, F, Finnin, BW, Koutsis, K, Arasaratnam, D, White, AJ, Rafii, A, Ng, ES, et al.
SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development..
Stem Cell Res
13(1)
:
172 -179
2014
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