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Details

Role Group Leader / Snr Princ Research Fellow
Research area Stem Cell Medicine

Contact

Available for student supervision
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute (MCRI). Prof Elefanty's research focuses on the differentiation of human pluripotent stem cells to understand and model blood diseases in vitro and for transplantation. Together with the laboratories of Professor Ed Stanley (Immune Development group) and Dr Elizabeth Ng (Blood Development group) at MCRI, Prof Elefanty has made important contributions to the generation of genetically modified human stem cell lines in which lineage-specific fluorescent reporters allow monitoring of differentiation.

After training as a physician, Professor Elefanty completed a PhD in leukaemogenesis at the Walter and Eliza Hall Institute of Medical Research supervised by Professor Suzanne Cory. He subsequently worked on globin gene regulation with Professor Frank Grosveld at the National Institute for Medical Research in Mill Hill, London before returning to the Hall Institute to pursue interests in developmental haematopoiesis and the differentiation of mouse embryonic stem cells.

He moved to Monash University in 2002 to initiate studies with human embryonic stem cells. In 2013, his laboratory relocated to the Murdoch Children’s Research Institute. In collaboration with Dr Elizabeth Ng and Prof Ed Stanley, he has focused on haematopoietic differentiation of human pluripotent stem cells.

Professor Elefanty holds active collaborations with:
• Professor Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Dr Elizabeth Ng, Blood Development Laboratory, Murdoch Children's Research Institute
• Professor Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Professor Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute (MCRI). Prof Elefanty's research focuses on the differentiation of human pluripotent stem cells to understand and model...
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute (MCRI). Prof Elefanty's research focuses on the differentiation of human pluripotent stem cells to understand and model blood diseases in vitro and for transplantation. Together with the laboratories of Professor Ed Stanley (Immune Development group) and Dr Elizabeth Ng (Blood Development group) at MCRI, Prof Elefanty has made important contributions to the generation of genetically modified human stem cell lines in which lineage-specific fluorescent reporters allow monitoring of differentiation.

After training as a physician, Professor Elefanty completed a PhD in leukaemogenesis at the Walter and Eliza Hall Institute of Medical Research supervised by Professor Suzanne Cory. He subsequently worked on globin gene regulation with Professor Frank Grosveld at the National Institute for Medical Research in Mill Hill, London before returning to the Hall Institute to pursue interests in developmental haematopoiesis and the differentiation of mouse embryonic stem cells.

He moved to Monash University in 2002 to initiate studies with human embryonic stem cells. In 2013, his laboratory relocated to the Murdoch Children’s Research Institute. In collaboration with Dr Elizabeth Ng and Prof Ed Stanley, he has focused on haematopoietic differentiation of human pluripotent stem cells.

Professor Elefanty holds active collaborations with:
• Professor Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Dr Elizabeth Ng, Blood Development Laboratory, Murdoch Children's Research Institute
• Professor Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Professor Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California

Top Publications

  • Soh, C-L, Giudice, A, Jenny, RA, Elliott, DA, Hatzistavrou, T, Micallef, SJ, Kianizad, K, Seach, N, Zúñiga-Pflücker, JC, Chidgey, AP, et al. FOXN1 (GFP/w) reporter hESCs enable identification of integrin-β4, HLA-DR, and EpCAM as markers of human PSC-derived FOXN1(+) thymic epithelial progenitors.. Stem Cell Reports 2(6) : 925 -937 2014
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  • Loh, KM, Ang, LT, Zhang, J, Kumar, V, Ang, J, Auyeong, JQ, Lee, KL, Choo, SH, Lim, CYY, Nichane, M, et al. Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations.. Cell Stem Cell 14(2) : 237 -252 2014
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  • Schiesser, JV, Micallef, SJ, Hawes, S, Elefanty, AG, Stanley, EG. Derivation of insulin-producing beta-cells from human pluripotent stem cells.. Rev Diabet Stud 11(1) : 6 -18 2014
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  • Takasato, M, Er, PX, Becroft, M, Vanslambrouck, JM, Stanley, EG, Elefanty, AG, Little, MH. Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney.. Nat Cell Biol 16(1) : 118 -126 2014
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  • Cao, J, Ng, ES, McNaughton, D, Stanley, EG, Elefanty, AG, Tobin, MJ, Heraud, P. The characterisation of pluripotent and multipotent stem cells using Fourier transform infrared microspectroscopy.. Int J Mol Sci 14(9) : 17453 -17476 2013
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