Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute (MCRI). Prof Elefanty's research focuses on the differentiation of human pluripotent stem cells to understand and model blood diseases in vitro and for transplantation. Together with the laboratories of Professor Ed Stanley (Immune Development group) and Dr Elizabeth Ng (Blood Development group) at MCRI, Prof Elefanty has made important contributions to the generation of genetically modified human stem cell lines in which lineage-specific fluorescent reporters allow monitoring of differentiation.
After training as a physician, Professor Elefanty completed a PhD in leukaemogenesis at the Walter and Eliza Hall Institute of Medical Research supervised by Professor Suzanne Cory. He subsequently worked on globin gene regulation with Professor Frank Grosveld at the National Institute for Medical Research in Mill Hill, London before returning to the Hall Institute to pursue interests in developmental haematopoiesis and the differentiation of mouse embryonic stem cells.
He moved to Monash University in 2002 to initiate studies with human embryonic stem cells. In 2013, his laboratory relocated to the Murdoch Children’s Research Institute. In collaboration with Dr Elizabeth Ng and Prof Ed Stanley, he has focused on haematopoietic differentiation of human pluripotent stem cells.
Professor Elefanty holds active collaborations with:
• Professor Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Dr Elizabeth Ng, Blood Development Laboratory, Murdoch Children's Research Institute
• Professor Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Professor Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute (MCRI). Prof Elefanty's research focuses on the differentiation of human pluripotent stem cells to understand and model...
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute (MCRI). Prof Elefanty's research focuses on the differentiation of human pluripotent stem cells to understand and model blood diseases in vitro and for transplantation. Together with the laboratories of Professor Ed Stanley (Immune Development group) and Dr Elizabeth Ng (Blood Development group) at MCRI, Prof Elefanty has made important contributions to the generation of genetically modified human stem cell lines in which lineage-specific fluorescent reporters allow monitoring of differentiation.
After training as a physician, Professor Elefanty completed a PhD in leukaemogenesis at the Walter and Eliza Hall Institute of Medical Research supervised by Professor Suzanne Cory. He subsequently worked on globin gene regulation with Professor Frank Grosveld at the National Institute for Medical Research in Mill Hill, London before returning to the Hall Institute to pursue interests in developmental haematopoiesis and the differentiation of mouse embryonic stem cells.
He moved to Monash University in 2002 to initiate studies with human embryonic stem cells. In 2013, his laboratory relocated to the Murdoch Children’s Research Institute. In collaboration with Dr Elizabeth Ng and Prof Ed Stanley, he has focused on haematopoietic differentiation of human pluripotent stem cells.
Professor Elefanty holds active collaborations with:
• Professor Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Dr Elizabeth Ng, Blood Development Laboratory, Murdoch Children's Research Institute
• Professor Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Professor Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Top Publications
Skelton, RJ, Arasaratnam, D, Finnin, BW, Haynes, JM, White, A, Ardehali, R, Elefanty, AG, Stanley, EG, Elliott, DA.
Abstract 137: VCAM1 and SIRPA Cell Surface Markers of Human Cardiomyocytes.
Circulation Research
113(suppl_1)
:
2013
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Cao, J, Ng, ES, McNaughton, D, Stanley, EG, Elefanty, AG, Tobin, MJ, Heraud, P.
Fourier transform infrared microspectroscopy reveals that tissue culture conditions affect the macromolecular phenotype of human embryonic stem cells..
Analyst
138(14)
:
4147 -4160
2013
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Maroof, AM, Keros, S, Tyson, JA, Ying, S-W, Ganat, YM, Merkle, FT, Liu, B, Goulburn, A, Stanley, EG, Elefanty, AG, et al.
Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells..
Cell Stem Cell
12(5)
:
559 -572
2013
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Nicholas, CR, Chen, J, Tang, Y, Southwell, DG, Chalmers, N, Vogt, D, Arnold, CM, Chen, Y-JJ, Stanley, EG, Elefanty, AG, et al.
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development..
Cell Stem Cell
12(5)
:
573 -586
2013
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Costa, M, Sourris, K, Lim, SM, Yu, QC, Hirst, CE, Parkington, HC, Jokubaitis, VJ, Dear, AE, Liu, HB, Micallef, SJ, et al.
Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization..
Stem Cell Res
10(1)
:
103 -117
2013
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