Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council...
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Top Publications
Foster, JW, Brennan, FE, Hampikian, GK, Goodfellow, PN, Sinclair, AH, Lovell-Badge, R, Selwood, L, Renfree, MB, Cooper, DW, Graves, JA.
Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials..
Nature
359(6395)
:
531 -533
1992
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Berta, P, Hawkins, JR, Sinclair, AH, Taylor, A, Griffiths, BL, Goodfellow, PN, Fellous, M.
Genetic evidence equating SRY and the testis-determining factor..
Nature
348(6300)
:
448 -450
1990
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Sinclair, AH, Berta, P, Palmer, MS, Hawkins, JR, Griffiths, BL, Smith, MJ, Foster, JW, Frischauf, AM, Lovell-Badge, R, Goodfellow, PN.
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif..
Nature
346(6281)
:
240 -244
1990
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Palmer, MS, Sinclair, AH, Berta, P, Ellis, NA, Goodfellow, PN, Abbas, NE, Fellous, M.
Genetic evidence that ZFY is not the testis-determining factor..
Nature
342(6252)
:
937 -939
1989
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Sinclair, AH, Foster, JW, Spencer, JA, Page, DC, Palmer, M, Goodfellow, PN, Graves, JA.
Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials..
Nature
336(6201)
:
780 -783
1988
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