Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council...
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Top Publications
Hudson, QJ, Smith, CA, Sinclair, AH.
Conserved expression of a novel gene during gonadal development..
Dev Dyn
233(3)
:
1083 -1090
2005
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Warne, G, Grover, S, Hutson, J, Sinclair, A, Metcalfe, S, Northam, E, Freeman, J, Murdoch Childrens Research Institute Sex Study Group.
A long-term outcome study of intersex conditions..
J Pediatr Endocrinol Metab
18(6)
:
555 -567
2005
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Smith, CA, McClive, PJ, Sinclair, AH.
Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo..
Dev Dyn
233(1)
:
188 -193
2005
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Sarraj, M, McClive, PJ, Loveland, KL, Sinclair, AH.
218. Expression of Wsb2 in the mouse testis.
Reproduction Fertility and Development
17(9)
:
84
2005
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Schmid, M, Nanda, I, Hoehn, H, Schartl, M, Haaf, T, Buerstedde, J-M, Arakawa, H, Caldwell, RB, Weigend, S, Burt, DW, et al.
Second report on chicken genes and chromosomes 2005..
Cytogenet Genome Res
109(4)
:
415 -479
2005
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