Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council...
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Top Publications
Sarraj, MA, Wilmore, HP, McClive, PJ, Sinclair, AH.
Corrigendum to “Sox15 is up regulated in the embryonic mouse testis” [Gene Expression Patterns 3 (2003) 413–417].
Gene Expression Patterns
3(6)
:
785
2003
view publication
McClive, PJ, Hurley, TM, Sarraj, MA, van den Bergen, JA, Sinclair, AH.
Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad..
Genesis
37(2)
:
84 -90
2003
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Sarraj, MA, Wilmore, HP, McClive, PJ, Sinclair, AH.
Sox15 is up regulated in the embryonic mouse testis..
Gene Expr Patterns
3(4)
:
413 -417
2003
view publication
McClive, PJ, Sinclair, AH.
Type II and type IX collagen transcript isoforms are expressed during mouse testis development..
Biol Reprod
68(5)
:
1742 -1747
2003
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Smith, CA, Katz, M, Sinclair, AH.
DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos..
Biol Reprod
68(2)
:
560 -570
2003
view publication