Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council...
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Top Publications
Reed, KJ, Sinclair, AH.
FET-1: a novel W-linked, female specific gene up-regulated in the embryonic chicken ovary..
Mech Dev
119 Suppl 1:
S87 -S90
2002
view publication
Smith, CA, Hurley, TM, McClive, PJ, Sinclair, AH.
Restricted expression of DMRT3 in chicken and mouse embryos..
Mech Dev
119 Suppl 1:
S73 -S76
2002
view publication
Reed, KJ, Sinclair, AH.
FET-1: a novel W-linked, female specific gene up-regulated in the embryonic chicken ovary..
Gene Expr Patterns
2(1-2)
:
83 -86
2002
view publication
Smith, CA, Hurley, TM, McClive, PJ, Sinclair, AH.
Restricted expression of DMRT3 in chicken and mouse embryos..
Gene Expr Patterns
2(1-2)
:
69 -72
2002
view publication
Morrish, BC, Sinclair, AH.
Vertebrate sex determination: many means to an end..
Reproduction
124(4)
:
447 -457
2002
view publication