Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council...
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Top Publications
Shankara Narayana, N, Kean, A-M, Ewans, L, Ohnesorg, T, Ayers, KL, Watson, G, Vasilaras, A, Sinclair, AH, Twigg, SM, Handelsman, DJ.
Painful ovulation in a 46,XX SRY -ve adult male with SOX9 duplication..
Endocrinol Diabetes Metab Case Rep
2017:
2017
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Meyers-Wallen, VN, Boyko, AR, Danko, CG, Grenier, JK, Mezey, JG, Hayward, JJ, Shannon, LM, Gao, C, Shafquat, A, Rice, EJ, et al.
XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris)..
PLoS One
12(10)
:
e0186331
2017
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Gaff, CL, M Winship, I, M Forrest, S, P Hansen, D, Clark, J, M Waring, P, South, M, H Sinclair, A.
Erratum: Preparing for genomic medicine: a real world demonstration of health system change..
NPJ Genom Med
2:
31
2017
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Gaff, CL, M Winship, I, M Forrest, S, P Hansen, D, Clark, J, M Waring, P, South, M, H Sinclair, A.
Preparing for genomic medicine: a real world demonstration of health system change..
NPJ Genom Med
2:
16
2017
view publication
Croft, B, Ayers, K, Sinclair, A, Ohnesorg, T.
Review disorders of sex development: The evolving role of genomics in diagnosis and gene discovery..
Birth Defects Res C Embryo Today
108(4)
:
337 -350
2016
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