Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council...
Professor Andrew Sinclair is Deputy Director of the Murdoch Children’s Research Institute and a Professor in Translational Genomics in the Dept. of Paediatrics at the University of Melbourne.
He led a National Health & Medical Research Council Program focusing on the molecular genetics of gonad development and its impact on patients with differences of sex development (DSD). In this capacity he has forged formal linkages with both national and international clinicians, discovered new genes, developed a rapid genomic sequencing panel assay (now in clinical use) that has dramatically improved rates of diagnosis. Recently, he has differentiated human iPS (stem cells) into testis cell lineages for functional analysis of DSD patient variants.
As a Board Director of the Victorian Clinical Genetics Service he has had oversight for implementing a range of genomics applications into clinical service provision, in particular, clinically accredited exomes and whole genomes. He is one of the leaders of the Melbourne Genomics Health Alliance and a lead architect of the Australian Genomics Health Alliance both of which aim to implement genomics into the healthcare system to improve patient outcomes. He has received numerous national and international awards and in 2015 was elected a Fellow of the Australian Academy of Health and Medical Sciences.
Top Publications
Tucker, EJ, Grover, SR, Bachelot, A, Touraine, P, Sinclair, AH.
Premature Ovarian Insufficiency: New Perspectives on Genetic Cause and Phenotypic Spectrum..
Endocr Rev
37(6)
:
609 -635
2016
view publication
Gustin, SE, Stringer, JM, Hogg, K, Sinclair, AH, Western, PS.
FGF9, activin and TGFβ promote testicular characteristics in an XX gonad organ culture model..
Reproduction
152(5)
:
529 -543
2016
view publication
Juniarto, AZ, van der Zwan, YG, Santosa, A, Ariani, MD, Eggers, S, Hersmus, R, Themmen, APN, Bruggenwirth, HT, Wolffenbuttel, KP, Sinclair, A, et al.
Hormonal evaluation in relation to phenotype and genotype in 286 patients with a disorder of sex development from Indonesia..
Clin Endocrinol (Oxf)
85(2)
:
247 -257
2016
view publication
Koopman, P, Sinclair, A, Lovell-Badge, R.
Of sex and determination: marking 25 years of Randy, the sex-reversed mouse..
Development
143(10)
:
1633 -1637
2016
view publication
Wu, Z, Liang, R, Ohnesorg, T, Cho, V, Lam, W, Abhayaratna, WP, Gatenby, PA, Perera, C, Zhang, Y, Whittle, B, et al.
Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion..
PLoS Genet
12(5)
:
e1006067
2016
view publication