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Dr Cameron Osborne

Dr Cameron Osborne

Details

Role Senior Research Fellow
Research area Stem Cell Medicine
Dr Cameron Osborne is a Senior Research Fellow in the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. His research focuses on how genome organisation and nuclear structure influence genetic programs in development and disease. He has contributed experimental and computational methodological advances in mapping global long-range gene regulatory interactions.

After completing an undergraduate degree at Simon Fraser University, Vancouver, Canada, he obtained a PhD degree at Adelaide University, for his characterisation of gene regulatory elements, in the laboratory of Peter Cockerill. In his postdoctoral research in the laboratory of James Ellis at the Hospital for Sick Children, Toronto, Canada, he was awarded a fellowship by the Thalassemia Foundation of Canada to develop retroviral gene therapy vectors for the treatment of haemoglobinopathies. He then joined Peter Fraser’s group at the Babraham Institute, Cambridge, UK, where he researched beta-globin gene regulation and the nuclear organisation of transcription. He was awarded a Bennett Senior Fellowship (Blood Cancer UK) to set up a research group to study long-range gene regulation in leukaemia, which he continued after moving to King’s College London. He joined the Murdoch Children’s Research Institute in 2023.
Dr Cameron Osborne is a Senior Research Fellow in the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. His research focuses on how genome organisation and nuclear structure influence genetic programs in development and...
Dr Cameron Osborne is a Senior Research Fellow in the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. His research focuses on how genome organisation and nuclear structure influence genetic programs in development and disease. He has contributed experimental and computational methodological advances in mapping global long-range gene regulatory interactions.

After completing an undergraduate degree at Simon Fraser University, Vancouver, Canada, he obtained a PhD degree at Adelaide University, for his characterisation of gene regulatory elements, in the laboratory of Peter Cockerill. In his postdoctoral research in the laboratory of James Ellis at the Hospital for Sick Children, Toronto, Canada, he was awarded a fellowship by the Thalassemia Foundation of Canada to develop retroviral gene therapy vectors for the treatment of haemoglobinopathies. He then joined Peter Fraser’s group at the Babraham Institute, Cambridge, UK, where he researched beta-globin gene regulation and the nuclear organisation of transcription. He was awarded a Bennett Senior Fellowship (Blood Cancer UK) to set up a research group to study long-range gene regulation in leukaemia, which he continued after moving to King’s College London. He joined the Murdoch Children’s Research Institute in 2023.

Top Publications

  • Villiers, W, Kelly, A, He, X, Kaufman-Cook, J, Elbasir, A, Bensmail, H, Lavender, P, Dillon, R, Mifsud, B, Osborne, CS. Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia.. Nat Commun 14(1) : 724 2023
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  • Osborne, CS, Mifsud, B. Capturing genomic relationships that matter. Chromosome Research 25(1) : 15 -24 2017
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  • Debrand, E, Chakalova, L, Miles, J, Dai, Y-F, Goyenechea, B, Dye, S, Osborne, CS, Horton, A, Harju-Baker, S, Pink, RC, et al. An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain. PLOS ONE 14(8) : e0217532 2024
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  • Freire-Pritchett, P, Schoenfelder, S, Várnai, C, Wingett, SW, Cairns, J, Collier, AJ, García-Vílchez, R, Furlan-Magaril, M, Osborne, CS, Fraser, P, et al. Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells. eLife 6: e21926 2024
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  • Wood, CD, Veenstra, H, Khasnis, S, Gunnell, A, Webb, HM, Shannon-Lowe, C, Andrews, S, Osborne, CS, West, MJ. MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs. eLife 5: e18270 2024
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