Dr Elizabeth Ng is a Team Leader in the Blood Development Laboratory at the Murdoch Children's Research Institute (MCRI). After completing her undergraduate degree at the University of Melbourne, she received her PhD from Monash University in 2013. A major focus of her work is to generate transplantable haematopoietic stem cells (HSCs) from human pluripotent stem cells for tissue repair and regeneration, disease modeling and the testing of pharmaceuticals and other therapeutic products. Dr Ng has devised and patented protocols for haematopoietic differentiation together with a differentiation medium that supports the efficient production of large numbers of blood cells. APEL medium has been licensed and commercialised by STEMCELL Technologies. She has maintained a long-standing collaboration with Professor Andrew Elefanty (Blood Development) and Professor Ed Stanley (Immune Development), together making important contributions to the development of human pluripotent stem cell as a powerful experimental platform to drive advancement in differentiation systems, cell culture medium formulation and the use of genetic modifications of human pluripotent stem cell lines.
Her work has identified that the expression of the HOXA genes during differentiation is crucial for generating haematopoietic cells with a transcriptional profile similar to the 'preHSCs' seen in the aorta-gonad mesonephros (AGM) region of the human embryo. Her current work focuses upon the challenge of maturing these cells further to produce engraftable HSCs and to develop in vitro 'niches' that mimic the bone marrow in order to sustain them. Her work is supported by grants from the NHMRC, a research collaboration with CSL Ltd and she is currently a Principal Investigator of the Novo Nordisk Foundation Center for Stem Cell Medicine.
Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Dr Elizabeth Ng is a Team Leader in the Blood Development Laboratory at the Murdoch Children's Research Institute (MCRI). After completing her undergraduate degree at the University of Melbourne, she received her PhD from Monash University in 2013. A...
Dr Elizabeth Ng is a Team Leader in the Blood Development Laboratory at the Murdoch Children's Research Institute (MCRI). After completing her undergraduate degree at the University of Melbourne, she received her PhD from Monash University in 2013. A major focus of her work is to generate transplantable haematopoietic stem cells (HSCs) from human pluripotent stem cells for tissue repair and regeneration, disease modeling and the testing of pharmaceuticals and other therapeutic products. Dr Ng has devised and patented protocols for haematopoietic differentiation together with a differentiation medium that supports the efficient production of large numbers of blood cells. APEL medium has been licensed and commercialised by STEMCELL Technologies. She has maintained a long-standing collaboration with Professor Andrew Elefanty (Blood Development) and Professor Ed Stanley (Immune Development), together making important contributions to the development of human pluripotent stem cell as a powerful experimental platform to drive advancement in differentiation systems, cell culture medium formulation and the use of genetic modifications of human pluripotent stem cell lines.
Her work has identified that the expression of the HOXA genes during differentiation is crucial for generating haematopoietic cells with a transcriptional profile similar to the 'preHSCs' seen in the aorta-gonad mesonephros (AGM) region of the human embryo. Her current work focuses upon the challenge of maturing these cells further to produce engraftable HSCs and to develop in vitro 'niches' that mimic the bone marrow in order to sustain them. Her work is supported by grants from the NHMRC, a research collaboration with CSL Ltd and she is currently a Principal Investigator of the Novo Nordisk Foundation Center for Stem Cell Medicine.
Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Top Publications
Cao, J, Ng, ES, McNaughton, D, Stanley, EG, Elefanty, AG, Tobin, MJ, Heraud, P.
Fourier transform infrared microspectroscopy reveals unique phenotypes for human embryonic and induced pluripotent stem cell lines and their progeny..
J Biophotonics
7(10)
:
767 -781
2014
view publication
Andrea, D, Sturgeon, C, Awong, G, Kennedy, M, Ng, E, Stanley, E, Elefanty, A, Keller, G.
Declined Presentation Human definitive hemogenic endothelium represents a distinct lineage from arterial vascular endothelium.
Experimental Hematology
42(8)
:
s23
2014
view publication
Skelton, RJP, Costa, M, Anderson, DJ, Bruveris, F, Finnin, BW, Koutsis, K, Arasaratnam, D, White, AJ, Rafii, A, Ng, ES, et al.
SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development..
Stem Cell Res
13(1)
:
172 -179
2014
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Loh, KM, Ang, LT, Zhang, J, Kumar, V, Ang, J, Auyeong, JQ, Lee, KL, Choo, SH, Lim, CYY, Nichane, M, et al.
Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations..
Cell Stem Cell
14(2)
:
237 -252
2014
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Cao, J, Ng, ES, McNaughton, D, Stanley, EG, Elefanty, AG, Tobin, MJ, Heraud, P.
The characterisation of pluripotent and multipotent stem cells using Fourier transform infrared microspectroscopy..
Int J Mol Sci
14(9)
:
17453 -17476
2013
view publication