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Details

Role Theme Director - Stem Cell Biology
Research area Stem Cell Medicine

Contact

Available for student supervision
Professor Porrello is the Theme Director of Stem Cell Biology and Head of the Heart Regeneration Group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Prof Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Over the course of his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Prof Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.

After completing his PhD in Physiology at The University of Melbourne, Prof Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Prof Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Professor Porrello is the Theme Director of Stem Cell Biology and Head of the Heart Regeneration Group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for...
Professor Porrello is the Theme Director of Stem Cell Biology and Head of the Heart Regeneration Group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Prof Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Over the course of his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Prof Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.

After completing his PhD in Physiology at The University of Melbourne, Prof Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Prof Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.

Top Publications

  • Sadek, HA, Porrello, ER. Neonatal heart regeneration: Moving from phenomenology to regenerative medicine. Journal of Thoracic and Cardiovascular Surgery 159(6) : 2451 -2455 2020
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  • Bywater, MJ, Burkhart, DL, Straube, J, Sabò, A, Pendino, V, Hudson, JE, Quaife-Ryan, GA, Porrello, ER, Rae, J, Parton, RG, et al. Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity.. Nat Commun 11(1) : 1827 2020
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  • Sreejit, G, Abdel-Latif, A, Athmanathan, B, Annabathula, R, Dhyani, A, Noothi, SK, Quaife-Ryan, GA, Al-Sharea, A, Pernes, G, Dragoljevic, D, et al. Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction. Circulation 141(13) : 1080 -1094 2020
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  • Lock, MC, Tellam, RL, Darby, JRT, Soo, JY, Brooks, DA, Macgowan, CK, Selvanayagam, JB, Porrello, ER, Seed, M, Keller-Wood, M, et al. Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart. Physiological Genomics 52(3) : 143 -159 2020
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  • Mills, R, Humphrey, S, Fortuna, PRJ, Lor, M, Foster, S, Quaife-Ryan, G, Johnston, R, Dumenil, T, Bishop, C, Ruraraju, R, et al. Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical). 2020
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