Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute (MCRI). He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Professor Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Throughout his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Professor Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.
After completing his PhD in Physiology at the University of Melbourne, Professor Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Professor Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute (MCRI). He also directs the Melbourne Node of the recently established Novo Nordisk Foundation...
Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute (MCRI). He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Professor Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Throughout his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Professor Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.
After completing his PhD in Physiology at the University of Melbourne, Professor Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Professor Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Top Publications
Morrison, JL, Zhang, S, Tellam, RL, Brooks, DA, McMillen, IC, Porrello, ER, Botting, KJ.
Regulation of microRNA during cardiomyocyte maturation in sheep..
BMC Genomics
16(1)
:
541
2015
view publication
Sim, CB, Ziemann, M, Kaspi, A, Harikrishnan, KN, Ooi, J, Khurana, I, Chang, L, Hudson, JE, El-Osta, A, Porrello, ER.
Dynamic changes in the cardiac methylome during postnatal development..
FASEB J
29(4)
:
1329 -1343
2015
view publication
Voges, H, Mills, R, Porrello, E, Hudson, J.
An in vitro model of acute myocardial damage in human bioengineered heart muscle.
Heart Lung and Circulation
24:
s196
2015
view publication
Bernardo, BC, Nguyen, SS, Winbanks, CE, Gao, X-M, Boey, EJH, Tham, YK, Kiriazis, H, Ooi, JYY, Porrello, ER, Igoor, S, et al.
Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy..
FASEB J
28(12)
:
5097 -5110
2014
view publication
Porrello, ER, Olson, EN.
A neonatal blueprint for cardiac regeneration..
Stem Cell Res
13(3 Pt B)
:
556 -570
2014
view publication