Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute (MCRI). He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Professor Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Throughout his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Professor Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.
After completing his PhD in Physiology at the University of Melbourne, Professor Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Professor Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute (MCRI). He also directs the Melbourne Node of the recently established Novo Nordisk Foundation...
Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute (MCRI). He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Professor Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Throughout his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Professor Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.
After completing his PhD in Physiology at the University of Melbourne, Professor Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Professor Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Top Publications
Frith, JE, Porrello, ER, Cooper-White, JJ.
Concise review: new frontiers in microRNA-based tissue regeneration..
Stem Cells Transl Med
3(8)
:
969 -976
2014
view publication
Sim, CB, Ziemann, M, Harikrishnan, KN, Kaspi, A, Ooi, J, Chang, L, Khurana, I, Olson, EN, El-Osta, A, Porrello, ER.
Abstract 120: Genome-wide DNA Methylation Analysis Reveals Dynamic Changes in the Cardiac Methylome During Post-natal Heart Development.
Circulation Research
115(suppl_1)
:
2014
view publication
Aurora, AB, Porrello, ER, Tan, W, Mahmoud, AI, Hill, JA, Bassel-Duby, R, Sadek, HA, Olson, EN.
Macrophages are required for neonatal heart regeneration..
J Clin Invest
124(3)
:
1382 -1392
2014
view publication
Mahmoud, AI, Porrello, ER, Kimura, W, Olson, EN, Sadek, HA.
Surgical models for cardiac regeneration in neonatal mice..
Nat Protoc
9(2)
:
305 -311
2014
view publication
Hudson, JE, Porrello, ER.
The non-coding road towards cardiac regeneration..
J Cardiovasc Transl Res
6(6)
:
909 -923
2013
view publication