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Jinia Lilianty

Jinia Lilianty

Details

Role PhD Student
Research area Stem Cell Medicine

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Jinia Lilianty is a PhD student at the Musculoskeletal Research, Murdoch Children's Research Institute (MCRI).

Jinia completed her Bachelor of Science (Biotechnology) at the Atma Jaya Catholic University of Indonesia in 2012. During her undergraduate, she worked as a laboratory assistant and did internships at the Primate Research Centre, Indonesia and BIOTEC, National Science and Technology Development Agency (NSTDA), Thailand. Her undergraduate research is to differentiate hepatocytes from adipose tissue mesenchymal stem cells (AdMSC) of the long-tailed macaque (Macaca fascicularis). After graduating, she worked for three years as a Scientist at Prodia Widyahusada, one of the biggest clinical laboratories in Indonesia. In 2016-2018, she continued her study in Master in Biomedical Science at the University of Melbourne under the Australia Awards Scholarship. This was her first time joining Musculoskeletal Research and working under A/Prof. Shireen Lamandé and Prof. John Bateman.

In 2019, Jinia began her PhD supported by Musculoskeletal Research's research grant and the University of Melbourne Research Scholarship Fee Offset. Her project is to model collagen II (COL2A1) cartilage disorders in vitro and investigate the molecular pathology underlying these diseases. Her study could accelerate the discovery of new therapeutic approaches to help patients. Her project includes generating mutant induced pluripotent stem cells (iPSCs) using CRISPR/Cas9 gene editing, optimising cartilage and bone differentiation conditions, and using various techniques (i.e., protein analysis, imaging, and RNAseq) to identify the molecular pathogenic pathways of COL2A1 mutations. Outside her research, Jinia was actively involved in student activities, including becoming a Melbourne Children's Campus Research Students Association committee member, organising student symposiums, and volunteering as a host and mentor at the University of Melbourne Open Day.
Jinia Lilianty is a PhD student at the Musculoskeletal Research, Murdoch Children's Research Institute (MCRI).

Jinia completed her Bachelor of Science (Biotechnology) at the Atma Jaya Catholic University of Indonesia in 2012. During her...
Jinia Lilianty is a PhD student at the Musculoskeletal Research, Murdoch Children's Research Institute (MCRI).

Jinia completed her Bachelor of Science (Biotechnology) at the Atma Jaya Catholic University of Indonesia in 2012. During her undergraduate, she worked as a laboratory assistant and did internships at the Primate Research Centre, Indonesia and BIOTEC, National Science and Technology Development Agency (NSTDA), Thailand. Her undergraduate research is to differentiate hepatocytes from adipose tissue mesenchymal stem cells (AdMSC) of the long-tailed macaque (Macaca fascicularis). After graduating, she worked for three years as a Scientist at Prodia Widyahusada, one of the biggest clinical laboratories in Indonesia. In 2016-2018, she continued her study in Master in Biomedical Science at the University of Melbourne under the Australia Awards Scholarship. This was her first time joining Musculoskeletal Research and working under A/Prof. Shireen Lamandé and Prof. John Bateman.

In 2019, Jinia began her PhD supported by Musculoskeletal Research's research grant and the University of Melbourne Research Scholarship Fee Offset. Her project is to model collagen II (COL2A1) cartilage disorders in vitro and investigate the molecular pathology underlying these diseases. Her study could accelerate the discovery of new therapeutic approaches to help patients. Her project includes generating mutant induced pluripotent stem cells (iPSCs) using CRISPR/Cas9 gene editing, optimising cartilage and bone differentiation conditions, and using various techniques (i.e., protein analysis, imaging, and RNAseq) to identify the molecular pathogenic pathways of COL2A1 mutations. Outside her research, Jinia was actively involved in student activities, including becoming a Melbourne Children's Campus Research Students Association committee member, organising student symposiums, and volunteering as a host and mentor at the University of Melbourne Open Day.

Top Publications

  • Yammine, KM, Abularach, SM, Kim, S-Y, Bikovtseva, AA, Lilianty, J, Butty, VL, Schiavoni, RP, Bateman, JF, Lamandé, SR, Shoulders, MD. Chondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in a human cartilage model.. 2023
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  • Lamandé, SR, Ng, ES, Cameron, TL, Kung, LHW, Sampurno, L, Rowley, L, Lilianty, J, Patria, YN, Stenta, T, Hanssen, E, et al. Modeling human skeletal development using human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America 120(19) : e2211510120 2023
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  • Lilianty, J, Bateman, JF, Lamandé, SR. Generation of a heterozygous COL2A1 (p.G1113C) hypochondrogenesis mutation iPSC line, MCRIi019-A-7, using CRISPR/Cas9 gene editing. Stem Cell Research 56: 102515 2021
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  • Nur Patria, Y, Stenta, T, Lilianty, J, Rowley, L, Stanley, EG, Elefanty, AG, Bateman, JF, Lamandé, SR. CRISPR/Cas9 gene editing of a SOX9 reporter human iPSC line to produce two TRPV4 patient heterozygous missense mutant iPSC lines, MCRIi001-A-3 (TRPV4 p.F273L) and MCRIi001-A-4 (TRPV4 p.P799L). Stem Cell Research 48: 101942 2020
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  • Lilianty, J, Nur Patria, Y, Stanley, EG, Elefanty, AG, Bateman, JF, Lamandé, SR. Generation of a heterozygous COL2A1 (p.R989C) spondyloepiphyseal dysplasia congenita mutation iPSC line, MCRIi001-B, using CRISPR/Cas9 gene editing. Stem Cell Research 45: 101843 2020
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