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Details

Role Esteemed Honorary Fellow
Research area Stem Cell Medicine
Group Blood Development

Contact

Available for student supervision
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions

Top Publications

  • Lamandé, SR, Chessler, SD, Golub, SB, Byers, PH, Chan, D, Cole, WG, Sillence, DO, Bateman, JF. Endoplasmic reticulum-mediated quality control of type I collagen production by cells from osteogenesis imperfecta patients with mutations in the pro alpha 1 (I) chain carboxyl-terminal propeptide which impair subunit assembly.. J Biol Chem 270(15) : 8642 -8649 1995
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  • McQuillan, DJ, Richardson, MD, Bateman, JF. Matrix deposition by a calcifying human osteogenic sarcoma cell line (SAOS-2).. Bone 16(4) : 415 -426 1995
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  • Chan, D, Cole, WG, Rogers, JG, Bateman, JF. Type X collagen multimer assembly in vitro is prevented by a Gly618 to Val mutation in the alpha 1(X) NC1 domain resulting in Schmid metaphyseal chondrodysplasia.. J Biol Chem 270(9) : 4558 -4562 1995
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  • Chan, D, Rogers, JF, Bateman, JF, Cole, WG. Recurrent substitutions of arginine 789 by cysteine in pro-alpha 1 (II) collagen chains produce spondyloepiphyseal dysplasia congenita.. J Rheumatol Suppl 43: 37 -38 1995
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  • Chan, D, Cole, WG, Chow, CW, Mundlos, S, Bateman, JF. A COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagen by type I and III collagens in cartilage.. J Biol Chem 270(4) : 1747 -1753 1995
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