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Details

Role Esteemed Honorary Fellow
Research area Stem Cell Medicine
Group Blood Development

Contact

Available for student supervision
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions

Top Publications

  • Bateman, JF, Chan, D, Moeller, I, Hannagan, M, Cole, WG. A 5' splice site mutation affecting the pre-mRNA splicing of two upstream exons in the collagen COL1A1 gene. Exon 8 skipping and altered definition of exon 7 generates truncated pro alpha 1(I) chains with a non-collagenous insertion destabilizing the triple helix.. Biochem J 302 ( Pt 3)(Pt 3) : 729 -735 1994
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  • Lamandé, SR, McQuillan, DJ, Hocking, AM, Bateman, JF. The role of C-propeptide cysteines and the formation of interchain disulphide bonds in the homotrimeric assembly of type I collagen Proα1(I) chains. Matrix Biology 14(5) : 408 1994
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  • Toman, D, Starcher, B, Mascara, T, Robberson, D, Smith, C, Garrett, LA, Bateman, J, de Crombrugghe, B. Severe uterus dysfunction in transgenic mice harboring a crosslinking mutation in type III collagen. Matrix Biology 14(5) : 413 1994
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  • Bateman, JF, Golub, SB. Deposition and selective degradation of structurally-abnormal type I collagen in a collagen matrix produced by osteogenesis imperfecta fibroblasts in vitro.. Matrix Biol 14(3) : 251 -262 1994
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  • Fenton, SP, Lamande, SR, Hannagan, M, Stacey, A, Jaenisch, R, Bateman, JF. Genomic sequence of mouse COL1A1 encoding the collagen propeptides.. Biochim Biophys Acta 1216(3) : 469 -474 1993
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