Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Top Publications
Stacey, A, Bateman, J, Choi, T, Mascara, T, Cole, W, Jaenisch, R.
Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-alpha 1(I) collagen gene..
Nature
332(6160)
:
131 -136
1988
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Ng, KW, Gummer, PR, Michelangeli, VP, Bateman, JF, Mascara, T, Cole, WG, Martin, TJ.
Regulation of alkaline phosphatase expression in a neonatal rat clonal calvarial cell strain by retinoic acid..
J Bone Miner Res
3(1)
:
53 -61
1988
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Bateman, JF, Harley, V, Chan, D, Cole, WG.
Comprehensive analysis of collagen metabolism in vitro using [4(3H)]/[14C]proline dual-labeling and polyacrylamide gel electrophoresis..
Anal Biochem
168(1)
:
171 -175
1988
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Bateman, JF, Chan, D, Lamande, S, Mascara, T, Cole, WG.
Biochemical heterogeneity of type I collagen mutations in osteogenesis imperfecta..
Ann N Y Acad Sci
543:
95 -105
1988
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Bateman, JF, Pillow, JJ, Mascara, T, Medvedec, S, Ramshaw, JA, Cole, WG.
Cell-layer-associated proteolytic cleavage of the telopeptides of type I collagen in fibroblast culture..
Biochem J
245(3)
:
677 -682
1987
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