Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Top Publications
Bauer, A, Bateman, J, Lamande, S, Hanssen, E, Kirejczyk, SGM, Yee, M, Ramiche, A, Jagannathan, V, Welle, M, Leeb, T, et al.
Identification of two independentCOL5A1variants in dogs with Ehlers Danlos syndrome.
2019
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Dudek, M, Angelucci, C, Ruckshanthi, JPD, Wang, P, Mallikarjun, V, Lawless, C, Swift, J, Kadler, K, Hoyland, J, Lamande, S, et al.
Circadian time series proteomics reveals daily dynamics in cartilage physiology.
2019
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de Kroon, LMG, van den Akker, GGH, Brachvogel, B, Narcisi, R, Belluoccio, D, Jenner, F, Bateman, JF, Little, CB, Brama, PAJ, Blaney Davidson, EN, et al.
Identification of TGFβ-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets..
Bone
116:
67 -77
2018
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Lamandé, SR, Bateman, JF.
Collagen VI disorders: Insights on form and function in the extracellular matrix and beyond..
Matrix Biol
71-72:
348 -367
2018
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LA, M, EJ, M, LH, K, M, F, JM, W, R, G, JF, B, E, S, MD, B, RP, B-H.
Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism.
2018
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