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Details

Role Esteemed Honorary Fellow
Research area Stem Cell Medicine
Group Blood Development

Contact

Available for student supervision
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions

Top Publications

  • Lamandé, SR, Yuan, Y, Gresshoff, IL, Rowley, L, Belluoccio, D, Kaluarachchi, K, Little, CB, Botzenhart, E, Zerres, K, Amor, DJ, et al. Mutations in TRPV4 cause an inherited arthropathy of hands and feet.. Nat Genet 43(11) : 1142 -1146 2011
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  • Chan, BY, Fuller, ES, Russell, AK, Smith, SM, Smith, MM, Jackson, MT, Cake, MA, Read, RA, Bateman, JF, Sambrook, PN, et al. Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis.. Osteoarthritis Cartilage 19(7) : 874 -885 2011
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  • Kannu, P, Bateman, JF, Savarirayan, R. Reply. Arthritis & Rheumatism 63(2) : 569 -570 2011
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  • Cameron, TL, Bell, KM, Tatarczuch, L, Mackie, EJ, Rajpar, MH, McDermott, BT, Boot-Handford, RP, Bateman, JF. Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy.. PLoS One 6(9) : e24600 2011
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  • Tooley, LD, Zamurs, LK, Beecher, N, Baker, NL, Peat, RA, Adams, NE, Bateman, JF, North, KN, Baldock, C, Lamandé, SR. Collagen VI microfibril formation is abolished by an {alpha}2(VI) von Willebrand factor type A domain mutation in a patient with Ullrich congenital muscular dystrophy.. J Biol Chem 285(43) : 33567 -33576 2010
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