Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Top Publications
Bateman, JF, Boot-Handford, RP, Lamandé, SR.
Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations..
Nat Rev Genet
10(3)
:
173 -183
2009
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Kannu, P, Bateman, JF, Belluoccio, D, Fosang, AJ, Savarirayan, R.
Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis..
Arthritis Rheum
60(2)
:
325 -334
2009
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Wilson, R, Daniele, B, Chrisopher, L, Amanda, F, John, B.
Proteomics of mouse cartilage degradation in vitro.
Matrix Biology
27:
43 -44
2008
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Allen, JM, Brachvogel, B, Schlötzer-Schrehardt, U, Fitzgerald, J, Bateman, JF.
Mice deficient in the ECM protein WARP have nerve defects.
Matrix Biology
27:
39
2008
view publication