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Details

Role Group Leader / Co-Director BLC
Research area Bruce Lefroy Centre

Contact

Available for student supervision
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.

Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.

Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.

Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep)...
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.

Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.

Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.

Top Publications

  • Song, YJC, Halliday, GM, Holton, JL, Lashley, T, O'Sullivan, SS, McCann, H, Lees, AJ, Ozawa, T, Williams, DR, Lockhart, PJ, et al. Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression.. J Neuropathol Exp Neurol 68(10) : 1073 -1083 2009
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  • Wilson, GR, Tan, JT, Brody, KM, Taylor, JM, Delatycki, MB, Lockhart, PJ. Expression and localization of the Parkin co-regulated gene in mouse CNS suggests a role in ependymal cilia function.. Neurosci Lett 460(1) : 97 -101 2009
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  • Taylor, JM, Wu, R-M, Farrer, MJ, Delatycki, MB, Lockhart, PJ. Analysis of PArkin Co-Regulated Gene in a Taiwanese-ethnic Chinese cohort with early-onset Parkinson's disease.. Parkinsonism Relat Disord 15(6) : 417 -421 2009
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  • Taylor, JM, Wu, R-M, Lin, C-H, Delatycki, MB, Lockhart, PJ. Lack of evidence for association of a parkin promoter polymorphism with early-onset Parkinson's disease in a Chinese population.. Parkinsonism Relat Disord 15(2) : 149 -152 2009
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  • Taylor, JM, Delatycki, MB, Lockhart, PJ. Identification and validation of control cell lines for accurate parkin dosage analysis.. J Neurosci Methods 176(2) : 68 -71 2009
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