Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.
Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep)...
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.
Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Top Publications
Chen, L, Jin, J, Davis, J, Zhou, Y, Wang, Y, Liu, J, Lockhart, PJ, Zhang, J.
Oligomeric alpha-synuclein inhibits tubulin polymerization..
Biochem Biophys Res Commun
356(3)
:
548 -553
2007
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Wong, J, Farlie, P, Holbert, S, Lockhart, P, Thomas, PQ.
Polyalanine expansion mutations in the X-linked hypopituitarism gene SOX3 result in aggresome formation and impaired transactivation..
Front Biosci
12:
2085 -2095
2007
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Fahey, MC, Knight, MA, Shaw, JH, Gardner, RJM, du Sart, D, Lockhart, PJ, Delatycki, MB, Gates, PC, Storey, E.
Spinocerebellar ataxia type 14: study of a family with an exon 5 mutation in the PRKCG gene..
J Neurol Neurosurg Psychiatry
76(12)
:
1720 -1722
2005
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Jin, J, Meredith, GE, Chen, L, Zhou, Y, Xu, J, Shie, F-S, Lockhart, P, Zhang, J.
Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease..
Brain Res Mol Brain Res
134(1)
:
119 -138
2005
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Lockhart, PJ, Bounds, R, Hulihan, M, Kachergus, J, Lincoln, S, Lin, C-H, Wu, R-M, Farrer, MJ.
Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism..
Mov Disord
19(9)
:
1065 -1069
2004
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