Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.
Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep)...
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.
Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Top Publications
O'Farrell, C, Lockhart, PJ, Lincoln, S, De Lucia, M, Singleton, AB, Dickson, DW, Cookson, MR.
Biochemical characterization of torsinB..
Brain Res Mol Brain Res
127(1-2)
:
1 -9
2004
view publication
Furtado, S, Payami, H, Lockhart, PJ, Hanson, M, Nutt, JG, Singleton, AA, Singleton, A, Bower, J, Utti, RJ, Bird, TD, et al.
Profile of families with parkinsonism-predominant spinocerebellar ataxia type 2 (SCA2)..
Mov Disord
19(6)
:
622 -629
2004
view publication
Maraganore, DM, Lesnick, TG, Elbaz, A, Chartier-Harlin, M-C, Gasser, T, Krüger, R, Hattori, N, Mellick, GD, Quattrone, A, Satoh, J-I, et al.
UCHL1 is a Parkinson's disease susceptibility gene..
Ann Neurol
55(4)
:
512 -521
2004
view publication
Mata, IF, Lockhart, PJ, Farrer, MJ.
Parkin genetics: one model for Parkinson's disease..
Hum Mol Genet
13 Spec No 1:
R127 -R133
2004
view publication
Lockhart, PJ, Lincoln, S, Hulihan, M, Kachergus, J, Wilkes, K, Bisceglio, G, Mash, DC, Farrer, MJ.
DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function..
J Med Genet
41(3)
:
e22
2004
view publication