Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.
Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep)...
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.
Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Top Publications
Lockhart, PJ, Hulihan, M, Lincoln, S, Hussey, J, Skipper, L, Bisceglio, G, Wilkes, K, Farrer, MJ.
Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis..
DNA Seq
15(1)
:
9 -14
2004
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Lockhart, PJ, O'Farrell, CA, Farrer, MJ.
It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG)..
Mov Disord
19(1)
:
101 -104
2004
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Zimprich, A, Müller-Myhsok, B, Farrer, M, Leitner, P, Sharma, M, Hulihan, M, Lockhart, P, Strongosky, A, Kachergus, J, Calne, DB, et al.
The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval..
Am J Hum Genet
74(1)
:
11 -19
2004
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Lockhart, PJ, Kachergus, J, Lincoln, S, Hulihan, M, Bisceglio, G, Thomas, N, Dickson, D, Farrer, MJ.
Multiplication of the alpha-synuclein gene is not a common disease mechanism in Lewy body disease..
J Mol Neurosci
24(3)
:
337 -342
2004
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Cookson, MR, Lockhart, PJ, McLendon, C, O'Farrell, C, Schlossmacher, M, Farrer, MJ.
RING finger 1 mutations in Parkin produce altered localization of the protein..
Hum Mol Genet
12(22)
:
2957 -2965
2003
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