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Details

Role Group Leader / Co-Director BLC
Research area Bruce Lefroy Centre

Contact

Available for student supervision
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.

Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.

Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.

Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep)...
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.

Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.

Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.

Top Publications

  • Lee, WS, Baldassari, S, Chipaux, M, Adle-Biassette, H, Stephenson, SEM, Maixner, W, Harvey, AS, Lockhart, PJ, Baulac, S, Leventer, RJ. Gradient of brain mosaic RHEB variants causes a continuum of cortical dysplasia.. Ann Clin Transl Neurol 8(2) : 485 -490 2021
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  • Macdonald-Laurs, E, Bailey, CA, Barton, S, Yang, JY-M, Mandelstam, S, Macgregor, D, Lockhart, PJ, Leventer, RJ, Maixner, WJ, Harvey, AS. Clinical seizure manifestations in the absence of synaptic connections.. Epileptic Disord 23(1) : 167 -172 2021
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  • Stutterd, CA, Brock, S, Stouffs, K, Fanjul-Fernandez, M, Lockhart, PJ, McGillivray, G, Mandelstam, S, Pope, K, Delatycki, MB, Jansen, A, et al. Genetic heterogeneity of polymicrogyria: study of 123 patients using deep sequencing.. Brain Commun 3(1) : fcaa221 2021
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  • Ye, Z, Chatterton, Z, Pflueger, J, Damiano, JA, McQuillan, L, Harvey, AS, Malone, S, Do, H, Maixner, W, Schneider, A, et al. Cerebrospinal fluid liquid biopsy for detecting somatic mosaicism in brain.. Brain Commun 3(1) : fcaa235 2021
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  • Chang, JW, Reyes, SD, Faure-Kumar, E, Lam, SK, Lawlor, MW, Leventer, RJ, Lew, SM, Lockhart, PJ, Pope, K, Weiner, HL, et al. Clonally Focused Public and Private T Cells in Resected Brain Tissue From Surgeries to Treat Children With Intractable Seizures.. Front Immunol 12: 664344 2021
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