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Details

Role Group Leader / Co-Director BLC
Research area Bruce Lefroy Centre

Contact

Available for student supervision
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.

Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.

Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.

Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep)...
Professor Paul Lockhart is the Group Leader of Neurogenetic Research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute.

Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, with the aim of establishing a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.

Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded a NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 26 causal and >100 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.

Top Publications

  • Gao, Y, Wilson, GR, Bozaoglu, K, Elefanty, AG, Stanley, EG, Dottori, M, Lockhart, PJ. Generation of RAB39B knockout isogenic human embryonic stem cell lines to model RAB39B-mediated Parkinson's disease.. Stem Cell Res 28: 161 -164 2018
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  • Gao, Y, Wilson, GR, Stephenson, SEM, Bozaoglu, K, Farrer, MJ, Lockhart, PJ. The emerging role of Rab GTPases in the pathogenesis of Parkinson's disease.. Mov Disord 33(2) : 196 -207 2018
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  • Myers, KA, Nasioulas, S, Boys, A, McMahon, JM, Slater, H, Lockhart, P, Sart, DD, Scheffer, IE. ADGRV1 is implicated in myoclonic epilepsy.. Epilepsia 59(2) : 381 -388 2018
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  • da Silva, RV, Johannssen, HC, Wyss, MT, Roome, RB, Bourojeni, FB, Stifani, N, Marsh, APL, Ryan, MM, Lockhart, PJ, Leventer, RJ, et al. DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans.. Cell Rep 22(5) : 1105 -1114 2018
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  • Bahlo, M, Bennett, MF, Degorski, P, Tankard, RM, Delatycki, MB, Lockhart, PJ. Recent advances in the detection of repeat expansions with short-read next-generation sequencing.. F1000Res 7: 2018
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