photo of Dr Ruili Li

Dr Ruili Li

Dr Ruili Li

Details

Role Senior Research Fellow
Research area Clinical sciences
Group Surgery
Dr Ruili Li (BS, MS, Ph.D) is a senior research fellow at the Surgical Research group, Murdoch Children's Research Institute, Honorary research fellow at the Paediatric Department of Melbourne University, Australia.

Dr Li started her research in reproductive biology when she did her Master's degree at Beijing Agricultural University on cryopreservation of rabbit embryos. She then came to Australia and completed her Ph.D in cryopreservation of mouse, goat and sheep embryos and embryonic cell development on the attempt to isolate embryonic stem cells under the supervision of Prof. Alan Trounson and Prof. Euan Roberts.

Dr Li joined Prof Richard Harvey's lab at the Water and Eliza Hall Institute after her Ph.D completion and focused on the establishment of the gene knockout system using embryonic stem cells followed by many years' experience of generating and analysis of genetically modified mice. She gained lots of experience on molecular biology, developmental biology and haematology while she was working side-by-side with many experts there.

Dr Li joined Prof Andrew Sinclair's Lab at Murdoch Children’s Research Institute and studied germ cell development during sex determination with focus on the regulation of pluripotency and differentiation in early germ cells, which involved in generating transgenic mice with inducible gene expression (TCCre, TCGFP, MkxHA mice) using ES cells and tetraploid embryos as well as blastocyst injection. With Prof Sinclair and MCRI executive committee's support, Dr Li involved in the establishment of MCRI facility of the transgenic and embryo service by drafting the business plan and was subsequently appointed as the manager of the facility during 2009-2010.

Dr Li joined Prof John Hutson's group in 2010 and has been working on the research in undescended testis at the Surgical Research group at Murdoch Children’s Research Institute. Currently Dr Li leads the laboratory research on testis descent and gonocyte transformation into spermatogonial stem cells using various transgenic, gene-knockout and naturally mutated rodent models as well as human biopsies of undescended testis (UDT). The research focuses on understanding the cellular and molecular regulation of postnatal germ cell development aiming to prevent the problems related to undescended testis (UDT), which are infertility and testicular cancer in young adult men with a history of UDT.
Dr Ruili Li (BS, MS, Ph.D) is a senior research fellow at the Surgical Research group, Murdoch Children's Research Institute, Honorary research fellow at the Paediatric Department of Melbourne University, Australia.

Dr Li started her research in...
Dr Ruili Li (BS, MS, Ph.D) is a senior research fellow at the Surgical Research group, Murdoch Children's Research Institute, Honorary research fellow at the Paediatric Department of Melbourne University, Australia.

Dr Li started her research in reproductive biology when she did her Master's degree at Beijing Agricultural University on cryopreservation of rabbit embryos. She then came to Australia and completed her Ph.D in cryopreservation of mouse, goat and sheep embryos and embryonic cell development on the attempt to isolate embryonic stem cells under the supervision of Prof. Alan Trounson and Prof. Euan Roberts.

Dr Li joined Prof Richard Harvey's lab at the Water and Eliza Hall Institute after her Ph.D completion and focused on the establishment of the gene knockout system using embryonic stem cells followed by many years' experience of generating and analysis of genetically modified mice. She gained lots of experience on molecular biology, developmental biology and haematology while she was working side-by-side with many experts there.

Dr Li joined Prof Andrew Sinclair's Lab at Murdoch Children’s Research Institute and studied germ cell development during sex determination with focus on the regulation of pluripotency and differentiation in early germ cells, which involved in generating transgenic mice with inducible gene expression (TCCre, TCGFP, MkxHA mice) using ES cells and tetraploid embryos as well as blastocyst injection. With Prof Sinclair and MCRI executive committee's support, Dr Li involved in the establishment of MCRI facility of the transgenic and embryo service by drafting the business plan and was subsequently appointed as the manager of the facility during 2009-2010.

Dr Li joined Prof John Hutson's group in 2010 and has been working on the research in undescended testis at the Surgical Research group at Murdoch Children’s Research Institute. Currently Dr Li leads the laboratory research on testis descent and gonocyte transformation into spermatogonial stem cells using various transgenic, gene-knockout and naturally mutated rodent models as well as human biopsies of undescended testis (UDT). The research focuses on understanding the cellular and molecular regulation of postnatal germ cell development aiming to prevent the problems related to undescended testis (UDT), which are infertility and testicular cancer in young adult men with a history of UDT.

Top Publications

  • Hildorf, S, Hildorf, AE, Clasen-Linde, E, Cortes, D, Walther-Larsen, S, Li, R, Hutson, JM, Thorup, J. The Majority of Boys Having Orchidopexy for Congenital Nonsyndromic Cryptorchidism during Minipuberty Exhibited Normal Reproductive Hormonal Profiles. European Journal of Pediatric Surgery 32(01) : 026 -033 2021
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  • Hildorf, S, Cortes, D, Thorup, J, Clasen-Linde, E, Hutson, J, Li, R. During infancy low levels of follicle-stimulating hormone may result in high rate of germ cell apoptosis. Journal of Pediatric Surgery 56(12) : 2399 -2406 2021
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  • Burton, E, Abeydeera, SA, Sarila, G, Cho, H-J, Wu, S, Tien, MY, Hutson, J, Li, R. The role of gonadotrophins in gonocyte transformation during minipuberty. Pediatric Surgery International 36(11) : 1379 -1385 2020
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  • Sarila, G, Bao, T, Abeydeera, SA, Li, R, Mell, B, Joe, B, Catubig, A, Hutson, J. Interplay between collagenase and undescended testes in Adamts16 knockout rats. Journal of Pediatric Surgery 55(9) : 1952 -1958 2020
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  • Tien, MY, Abeydeera, SA, Cho, H-J, Sarila, G, Catubig, A, Burton, E, Hutson, J, Li, R. Does the apoptosis pathway play a critical role in gonocyte transformation?. Journal of Pediatric Surgery 55(9) : 1947 -1951 2019
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