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Details

Role Honorary Fellow
Research area Genomic Medicine
Dr Ruili Li (BS, MS, Ph.D) is a senior research fellow at the Surgical Research group, Murdoch Children's Research Institute, Honorary research fellow at the Paediatric Department of Melbourne University, Australia.

Dr Li started her research in reproductive biology when she did her Master's degree at Beijing Agricultural University on cryopreservation of rabbit embryos. She then came to Australia and completed her Ph.D in cryopreservation of mouse, goat and sheep embryos and embryonic cell development on the attempt to isolate embryonic stem cells under the supervision of Prof. Alan Trounson and Prof. Euan Roberts.

Dr Li joined Prof Richard Harvey's lab at the Water and Eliza Hall Institute after her Ph.D completion and focused on the establishment of the gene knockout system using embryonic stem cells followed by many years' experience of generating and analysis of genetically modified mice. She gained lots of experience on molecular biology, developmental biology and haematology while she was working side-by-side with many experts there.

Dr Li joined Prof Andrew Sinclair's Lab at Murdoch Children’s Research Institute and studied germ cell development during sex determination with focus on the regulation of pluripotency and differentiation in early germ cells, which involved in generating transgenic mice with inducible gene expression (TCCre, TCGFP, MkxHA mice) using ES cells and tetraploid embryos as well as blastocyst injection. With Prof Sinclair and MCRI executive committee's support, Dr Li involved in the establishment of MCRI facility of the transgenic and embryo service by drafting the business plan and was subsequently appointed as the manager of the facility during 2009-2010.

Dr Li joined Prof John Hutson's group in 2010 and has been working on the research in undescended testis at the Surgical Research group at Murdoch Children’s Research Institute. Currently Dr Li leads the laboratory research on testis descent and gonocyte transformation into spermatogonial stem cells using various transgenic, gene-knockout and naturally mutated rodent models as well as human biopsies of undescended testis (UDT). The research focuses on understanding the cellular and molecular regulation of postnatal germ cell development aiming to prevent the problems related to undescended testis (UDT), which are infertility and testicular cancer in young adult men with a history of UDT.
Dr Ruili Li (BS, MS, Ph.D) is a senior research fellow at the Surgical Research group, Murdoch Children's Research Institute, Honorary research fellow at the Paediatric Department of Melbourne University, Australia.

Dr Li started her research in...
Dr Ruili Li (BS, MS, Ph.D) is a senior research fellow at the Surgical Research group, Murdoch Children's Research Institute, Honorary research fellow at the Paediatric Department of Melbourne University, Australia.

Dr Li started her research in reproductive biology when she did her Master's degree at Beijing Agricultural University on cryopreservation of rabbit embryos. She then came to Australia and completed her Ph.D in cryopreservation of mouse, goat and sheep embryos and embryonic cell development on the attempt to isolate embryonic stem cells under the supervision of Prof. Alan Trounson and Prof. Euan Roberts.

Dr Li joined Prof Richard Harvey's lab at the Water and Eliza Hall Institute after her Ph.D completion and focused on the establishment of the gene knockout system using embryonic stem cells followed by many years' experience of generating and analysis of genetically modified mice. She gained lots of experience on molecular biology, developmental biology and haematology while she was working side-by-side with many experts there.

Dr Li joined Prof Andrew Sinclair's Lab at Murdoch Children’s Research Institute and studied germ cell development during sex determination with focus on the regulation of pluripotency and differentiation in early germ cells, which involved in generating transgenic mice with inducible gene expression (TCCre, TCGFP, MkxHA mice) using ES cells and tetraploid embryos as well as blastocyst injection. With Prof Sinclair and MCRI executive committee's support, Dr Li involved in the establishment of MCRI facility of the transgenic and embryo service by drafting the business plan and was subsequently appointed as the manager of the facility during 2009-2010.

Dr Li joined Prof John Hutson's group in 2010 and has been working on the research in undescended testis at the Surgical Research group at Murdoch Children’s Research Institute. Currently Dr Li leads the laboratory research on testis descent and gonocyte transformation into spermatogonial stem cells using various transgenic, gene-knockout and naturally mutated rodent models as well as human biopsies of undescended testis (UDT). The research focuses on understanding the cellular and molecular regulation of postnatal germ cell development aiming to prevent the problems related to undescended testis (UDT), which are infertility and testicular cancer in young adult men with a history of UDT.

Top Publications

  • Notini, AJ, Li, R, Western, PS, Sinclair, AH, White, SJ. Rapid and reliable determination of transgene zygosity in mice by multiplex ligation-dependent probe amplification.. Transgenic Res 18(6) : 987 -991 2009
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  • Western, P, Miles, D, van den Bergen, J, Li, R, Burton, M, Sinclair, A. DYNAMIC REGULATION OF CELL CYCLE AND PLURIPOTENCY IN THE FETAL MALE GERM LINE. Biology of Reproduction 77(Suppl_1) : 72 -72 2007
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  • Maldonado-Saldivia, J, van den Bergen, J, Krouskos, M, Gilchrist, M, Lee, C, Li, R, Sinclair, AH, Surani, MA, Western, PS. Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line.. Stem Cells 25(1) : 19 -28 2007
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  • Londrigan, SL, Sutherland, RM, Brady, JL, Zhan, Y, Li, R, Estella, E, Kay, TWH, Lew, AM. Prolonged local expression of anti-CD4 antibody by adenovirally transduced allografts can promote long-term graft survival.. J Gene Med 8(1) : 42 -52 2006
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  • Sims, NA, Jenkins, BJ, Nakamura, A, Quinn, JMW, Li, R, Gillespie, MT, Ernst, M, Robb, L, Martin, TJ. Interleukin-11 receptor signaling is required for normal bone remodeling.. J Bone Miner Res 20(7) : 1093 -1102 2005
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