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Role Princ Res Fellow, Lead, Bone & Cartilage
Research area Stem Cell Medicine
Group Blood Development

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Available for student supervision
Human skeletal development and correct bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research aims to understand the molecular basis of these disorders to improve diagnosis and genetic counselling, identify new therapeutic targets and test new treatments to ultimately improve the quality of life for children with these debilitating conditions
Human skeletal development and correct bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Human skeletal development and correct bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research aims to understand the molecular basis of these disorders to improve diagnosis and genetic counselling, identify new therapeutic targets and test new treatments to ultimately improve the quality of life for children with these debilitating conditions

Top Publications

  • Lamandé, SR, Bateman, JF. A type I collagen reporter gene construct for protein engineering studies. Functional equivalence of transfected reporter COL1A1 and endogenous gene products during biosynthesis and in vitro extracellular matrix accumulation. Biochemical Journal 293(2) : 387 -394 1993
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  • Lamandé, SR, Bateman, JF. A Mouse 3T6 Fibroblast Cell Culture Model for the Study of Normal and Protein-Engineered Collagen Synthesis and Deposition into the Extracellular Matrix. Matrix Biology 13(4) : 323 -330 1993
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  • Bateman, JF, Lamande, SR, Hannagan, M, Moeller, I, Dahl, HM, Cole, WG. Chemical cleavage method for the detection of RNA base changes: Experience in the application to collagen mutations in osteogenesis imperfecta. American Journal of Medical Genetics 45(2) : 233 -240 1993
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  • Cole, WG, Chiodo, AA, Lamande, SR, Janeczko, R, Ramirez, F, Dahl, HH, Chan, D, Bateman, JF. A base substitution at a splice site in the COL3A1 gene causes exon skipping and generates abnormal type III procollagen in a patient with Ehlers-Danlos syndrome type IV.. Journal of Biological Chemistry 265(28) : 17070 -17077 1990
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  • Chan, D, Lamande, SR, Cole, WG, Bateman, JF. Regulation of procollagen synthesis and processing during ascorbate-induced extracellular matrix accumulation in vitro. Biochemical Journal 269(1) : 175 -181 1990
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