Wei Shern Lee
Wei Shern Lee
Wei Shern Lee is an Honorary Fellow at the Neurogenetic Research group led by Professor Paul Lockhart. After finishing his PhD in 2021, Wei was awarded the MCRI Early Career Research Fellowship to continue his research on understanding the genetic basis and pathogenic mechanism of developmental brain malformations, a significant cause of drug-resistant focal epilepsy.
Wei has a strong interest in the application of genomic technologies to improve disease diagnosis and understand disease mechanisms. His research at MCRI focused on the investigation of epileptic brain tissue using deep sequencing approaches and single-cell technologies. The ultimate goals are twofold: 1. To progress basic science and the understanding of brain development, and 2. To facilitate the development of novel therapeutic approaches tailored to the specific genetic fault underlying each patient’s condition.
Wei has a strong interest in the application of genomic technologies to improve disease diagnosis and understand disease mechanisms. His research at MCRI focused on the investigation of epileptic brain tissue using deep sequencing approaches and single-cell technologies. The ultimate goals are twofold: 1. To progress basic science and the understanding of brain development, and 2. To facilitate the development of novel therapeutic approaches tailored to the specific genetic fault underlying each patient’s condition.
Wei Shern Lee is an Honorary Fellow at the Neurogenetic Research group led by Professor Paul Lockhart. After finishing his PhD in 2021, Wei was awarded the MCRI Early Career Research Fellowship to continue his research on understanding the genetic...
Wei Shern Lee is an Honorary Fellow at the Neurogenetic Research group led by Professor Paul Lockhart. After finishing his PhD in 2021, Wei was awarded the MCRI Early Career Research Fellowship to continue his research on understanding the genetic basis and pathogenic mechanism of developmental brain malformations, a significant cause of drug-resistant focal epilepsy.
Wei has a strong interest in the application of genomic technologies to improve disease diagnosis and understand disease mechanisms. His research at MCRI focused on the investigation of epileptic brain tissue using deep sequencing approaches and single-cell technologies. The ultimate goals are twofold: 1. To progress basic science and the understanding of brain development, and 2. To facilitate the development of novel therapeutic approaches tailored to the specific genetic fault underlying each patient’s condition.
Wei has a strong interest in the application of genomic technologies to improve disease diagnosis and understand disease mechanisms. His research at MCRI focused on the investigation of epileptic brain tissue using deep sequencing approaches and single-cell technologies. The ultimate goals are twofold: 1. To progress basic science and the understanding of brain development, and 2. To facilitate the development of novel therapeutic approaches tailored to the specific genetic fault underlying each patient’s condition.
Top Publications
- Lee, WS, Stephenson, SEM, Pope, K, Gillies, G, Maixner, W, Macdonald-Laurs, E, MacGregor, D, D'Arcy, C, Jackson, G, Harvey, AS, et al. Genetic characterization identifies bottom-of-sulcus dysplasia as an mTORopathy.. Neurology 95(18) : e2542 -e2551 2020 view publication
- Macdonald-Laurs, E, Warren, AEL, Francis, P, Mandelstam, SA, Lee, WS, Coleman, M, Stephenson, SEM, Barton, S, D'Arcy, C, Lockhart, PJ, et al. The clinical, imaging, pathological and genetic landscape of bottom-of-sulcus dysplasia.. Brain 147(4) : 1264 -1277 2024 view publication
- Stephenson, SE, Owens, HG, Richards, KL, Lee, WS, D’Arcy, C, Barton, S, Mandelstam, SA, Maixner, WJ, MacGregor, D, Petrou, S, et al. Dysmorphic neuron density underlies intrinsic epileptogenicity of the centre of cortical tubers. 621607 2024 view publication
- Lee, WS, Lockhart, PJ. Utility of droplet digital polymerase chain reaction for studying somatic mosaicism: brain malformations and beyond.. Neural Regen Res 18(11) : 2389 -2390 2023 view publication
- Lee, WS, Macdonald-Laurs, E, Stephenson, S, D'Arcy, C, Maixner, W, Harvey, AS, Lockhart, PJ, Leventer, RJ. Pathogenic RHEB Somatic Variant in a Child With Tuberous Sclerosis Complex Without Pathogenic Variants in TSC1 or TSC2.. Neurology 101(2) : 78 -82 2023 view publication
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