Wei Shern Lee
Wei Shern Lee
Details
Role
Research Officer
Group
Neurogenetics (BLC)
Wei Shern Lee is a Research Officer at the Neurogenetic Research Group led by Prof. Paul Lockhart. After finishing his PhD in 2021, Wei was awarded the MCRI Early Career Research Fellowship to continue his research on the genetic basis and pathogenic mechanism of developmental brain malformations, which are a significant cause of drug-resistant focal epilepsy.
Wei has a strong interest in the application of next generation sequencing technologies to understand disease mechanisms. His research investigates epileptic brain tissue using deep sequencing approaches and single cell technologies. The ultimate goals are twofold: 1. To progress basic science and the understanding of brain development, and 2. To develop novel therapeutic approaches tailored to the specific genetic fault underlying each patient’s condition.
Wei has a strong interest in the application of next generation sequencing technologies to understand disease mechanisms. His research investigates epileptic brain tissue using deep sequencing approaches and single cell technologies. The ultimate goals are twofold: 1. To progress basic science and the understanding of brain development, and 2. To develop novel therapeutic approaches tailored to the specific genetic fault underlying each patient’s condition.
Wei Shern Lee is a Research Officer at the Neurogenetic Research Group led by Prof. Paul Lockhart. After finishing his PhD in 2021, Wei was awarded the MCRI Early Career Research Fellowship to continue his research on the genetic basis and pathogenic...
Wei Shern Lee is a Research Officer at the Neurogenetic Research Group led by Prof. Paul Lockhart. After finishing his PhD in 2021, Wei was awarded the MCRI Early Career Research Fellowship to continue his research on the genetic basis and pathogenic mechanism of developmental brain malformations, which are a significant cause of drug-resistant focal epilepsy.
Wei has a strong interest in the application of next generation sequencing technologies to understand disease mechanisms. His research investigates epileptic brain tissue using deep sequencing approaches and single cell technologies. The ultimate goals are twofold: 1. To progress basic science and the understanding of brain development, and 2. To develop novel therapeutic approaches tailored to the specific genetic fault underlying each patient’s condition.
Wei has a strong interest in the application of next generation sequencing technologies to understand disease mechanisms. His research investigates epileptic brain tissue using deep sequencing approaches and single cell technologies. The ultimate goals are twofold: 1. To progress basic science and the understanding of brain development, and 2. To develop novel therapeutic approaches tailored to the specific genetic fault underlying each patient’s condition.
Top Publications
- Lee, WS, Stephenson, SEM, Pope, K, Gillies, G, Maixner, W, Macdonald-Laurs, E, MacGregor, D, D'Arcy, C, Jackson, G, Harvey, AS, et al. Genetic characterization identifies bottom-of-sulcus dysplasia as an mTORopathy.. Neurology 95(18) : e2542 -e2551 2020 view publication
- Lee, WS, Baldassari, S, Stephenson, SEM, Lockhart, PJ, Baulac, S, Leventer, RJ. Cortical Dysplasia and the mTOR Pathway: How the Study of Human Brain Tissue Has Led to Insights into Epileptogenesis. International Journal of Molecular Sciences 23(3) : 1344 2022 view publication
- Ye, Z, Chatterton, Z, Pflueger, J, Damiano, JA, McQuillan, L, Harvey, AS, Malone, S, Do, H, Maixner, W, Schneider, A, et al. Cerebrospinal fluid liquid biopsy for detecting somatic mosaicism in brain. Brain Communications 3(1) : fcaa235- 2021 view publication
- Lee, WS, Baldassari, S, Chipaux, M, Adle‐Biassette, H, Stephenson, SEM, Maixner, W, Harvey, AS, Lockhart, PJ, Baulac, S, Leventer, RJ. Gradient of brain mosaic RHEB variants causes a continuum of cortical dysplasia. Annals of Clinical and Translational Neurology 8(2) : 485 -490 2021 view publication
- Bozaoglu, K, Shern Lee, W, Haebich, KM, North, KN, Payne, JM, Lockhart, PJ. Generation of four iPSC lines from Neurofibromatosis Type 1 patients. Stem Cell Research 49: 102013 2020 view publication
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