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Professor Yves D'Udekem
Associate Professor Yves d'Udekem has acquired international leadership as an academic surgeon in the field of paediatric cardiac surgery. He migrated from Belgium to Australia in 2003 to work at The Royal Children's Hospital. His research career is following an ascending trajectory at the Hospital, which is now one of the world leading centres in paediatric cardiac surgery. His current main research focus is the long-term outcome of patients born with a single ventricle who have undergone a Fontan operation. He is now leading the world's largest and most in-depth research of its kind in this patient population.
- 2014: Mentee Dr A.Iyengar awarded the American Association of Thoracic Surgery Resident' Scientific Poster Competition (Congenital)
- 2012: Best trainee oral presentation.The 4 th Congress of Asio-Pacicfic Pediatric Cardiac Society.
April 4-7 2012, Taipei, Taiwan.
- 2011: Winner of the Blue Ribbon as the top congenital poster in the 47 th Annual meeting ofSociety of Thoracic Surgeons, Jan31-Feb 02 2011, San Diego, CA.
- 2011: Top ranked Heart Foundation Career Development Fellow in Victoria.
- 2010: Murdoch Childrens Research Institute Innovation award
Associate Professor d'Udekem's research is centred around the long-term consequences of cardiac operations. This research is mainly retrospective, performed on large populations and essentially practical, as it is aimed at modifying surgical techniques and refining management strategies of patients born with congenital heart disease. It resulted in landmarks publications about tetralogy of Fallot, Fontan procedure, aortic valve repair and aortic arch repair.
He has currently two research foci: the outcomes late after Fontan surgery and after aortic arch repair. He is leading a nationally funded research project aiming at building a national database gathering all heath information of Fontan patients in Australia and New Zealand. This work is today the largest of its kind in the world.
He has published 125 articles in international peer-reviewed journals. In the last five year he published 70 articles and obtained 11 grants (5 National Health and Medical Research Council (NHMRC) grants, two as Chief Investigator).
Tetralogy of Fallot: His work determined that the role of the incision of the right ventricular outflow tract was predominant in the genesis of biventricular dilatation late after Fallot. Initially controversial, but now accepted findings, has led to change in the way the Tetralogy of Fallot is done at birth and in the way the operation is performed.
Aortic Valve Repair: His clinical research work on aortic valve repair led to a paradigm shift. Up to now the majority of paediatric patients with aortic valve disease will undergo balloon dilatation. This work is now demonstrating that surgery provides a better and longer-lasting clinical result. This work is the topic of heated debate in all of the largest world conferences and is changing the practice.
Aortic Arch Repair: His work on the late consequence of late arch repair demonstrated that the incidence of late hypertension was much higher than expected. His work has led to enlarging the indication for more extensive operation in order to avoid the occurrence of late hypertension.
Tetralogy, Pulmonary Atresia, MAPCA: His work has led to a new management strategy for this condition.
Single Ventricle: His whole work for the last few years on late outcome after single ventricle operations and has defined indications for these various surgeries.
d'Udekem Y, Iyengar AJ, Galati JC, Weintraub RG, Wheaton GR, Bullock A, Justo RN, Grigg LE, Hope S, Forsdick V, Radford DJ, Gentles TL, Celermajer DS, Winlaw DS, Redefining Expectations of Long-Term Survival After the Fontan Procedure: 25 Years of Follow-Up From the Entire Population of Australia and New Zealand. Circulation. 2014 (Epub ahead of print)
d'Udekem Y, Galati JC, Konstantinov IE, Cheung MH, Brizard CP. Intersurgeon variability in long-term outcomes after transatrial repair of tetralogy of Fallot: 25 years' experience with 675 patients. J Thoracic Cardiovasc Surg. 2014 Mar;147(3):880-6
d'Udekem Y, Galati JC, Rolley GJ, Konstantinov IE, Weintraub RG, Grigg L et al. Low Risk Pulmonary Valve Implantation after a Policy of Transatrial Repair of Tetralogy of Fallot delayed beyond the neonatal period: The Melbourne Experience over 25 years. J Am Coll Cardiol. 2014 Feb 18;63(6):563-8
Siddiqui J, Brizard CP, Iyegnar AJ, Hutchinson D, Konstantinov IE, Wheaton GR, Ramsay JM, d'Udekem Y. Surgical valvotomy and repair for neonatal and infant congenital aortic stenosis achieves better results than interventional catheterisation. J Am Coll Cardiol. 2013 Dec 3;62(22):2134-4
d'Udekem Y, Siddiqui J, Seaman CS, Konstantinov IE, Galati JC, Cheung MM, Brizard CP. Long-term results of a strategy of aortic valve repair in the pediatric population. J Thorac Cardiovascular Surg. 2013 Feb; 145(2):461-7; discussion 467-9.
Lee MG, Kowalski R, Galati JC, Cheung MM, Jones B, Koleff J, d'Udekem Y. Twenty-four-hour ambulatory blood pressure monitoring detects a high prevalence of hypertension late after coarctation repair in patients with hypoplastic arches. J Thorac Cardiovasc Surg. 2012 Nov; 144(5):1110-8.
d'Udekem Y, Xu M, Galati J, Lu S, Iyengar AJ, Konstantinov IE, Wheaton G, Ramsay J, Grigg L, Millar J, Cheung MH, Brizard CP. Predictors of Survival after Single Ventricle Palliation: The Impact of Right Ventricular Dominance. J Am Coll Cardiol. 2012 Mar 27; 59(13):1178-85.
Hussein A, Iyengar AJ, Jones B, Donath S, Konstantinov I, Grigg LE, Wheaton G, Bullock A, Brizard CP, d'Udekem Y. Twenty Three years of One-stage End-to-Side Anastomosis Repair of Interrupted Aortic Arches. J Thorac Cardiovasc Surg 2010 Apr; 139: 942-9.
d'Udekem Y, Cheung M, Setyapranata S, Iyengar AJ, Kelly P, Buckland N, Grigg L, Weintraub RG, Cochrane AD, Vance A, Brizard CP, Penny DJ. How good is a good Fontan? Quality of life and exercise capacity of Fontans without Arrhythmias. Ann of Thorac Surg 2009 Dec; 88: 1961-9.
d'Udekem Y. Aortic valve surgery in children. Heart. 2011 Jul; 97(14):1182-9.
Yves has received 11 grants in the last five years. He was CIA in four NHMRC grants in the last five years.