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Dr David Martino
Dr Martino is a National Health and Medical Research Council (NHMRC) Peter Doherty fellow in the field of epigenetics in allergic disease . He completed his PhD at the University of Western Australia on the topic of gene expression profiling in children with food allergy. He currently holds a Post-doctoral position with the Centre for Food and Allergy Research and an Honorary Research Fellow appointment with the University of Melbourne.
- Peter Doherty Early Career Fellowship, NHRMC, 2013
- Oral presentation award, EAACI, 2013
- Outstanding abstract award, World Allergy Organization, 2012
- Young Investigator oral presentation prize, Australian Epigenetics Alliance, 2011
Dr Martino's current research interests involve epigenetic regulation and programming of immune development in health and disease. He has a strong passion for genomics, bioinformatics and systems-wide approaches to studying complex diseases.
- Understanding epigenetic mechanism of T-cell function in food allergy
- Discovery of DNA methylation biomarkers predictive of disease
- The role of HLA genes in the risk for food allergy.
Martino, D., Joo, J. E., Sexton-Oates, A., Dang, T., Allen, K., Saffery, R., & Prescott, S. (2014). Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy. Epigenetics : Official Journal of the DNA Methylation Society, 9(7)
Manori Amarasekera, David Martino, Sarah Ashley, Hani Harb, Dörthe Kesper, Deborah Strickland, Richard Saffery, and Susan L. Prescott,. Genome-wide DNA methylation profiling identifies a folate-sensitive region of differential methylation upstream of ZFP57 imprinting regulator in humans. FASEB, accepted for publication May 2014
Jihoon E Joo, Ursula Hiden, Luciana Lassance, Lavinia Gordon, David J Martino, Gernot Desoye and Richard Saffery. Variable promoter methylation contributes to differential expression of key genes in human placenta-derived venous and arterial endothelial cells. BMC Genomics. 2013, 14(1) pp.475
Martino D, Loke YJ, Gordon L, Ollikainen M, Cruickshank MN, Saffery R, Craig JM (2013) Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance. Genome Biol 14:R42
Martino, D., Holt, P. & Prescott, S. A novel role for interleukin-1 receptor signalling in the developmental regulation of immune responses to endotoxin. Pediatr Allergy Immunol (2012).doi:10.1111/j.1399-3038.2012.01287.x
Martino, D., Maksimovic, J., Joo, J.-H., Prescott, S. L. & Saffery R Genome-scale profiling reveals a subset of genes regulated by DNA methylation that program somatic T-cell phenotypes in humans. Genes Immun. (2012).doi:10.1038/gene.2012.7
Martino, D. J. et al. Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humans. Epigenetics 6, (2011)
Martino, D. J. et al. T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy. Allergy 67, 191–200 (2012)
N.D'Vaz, S J Meldrum, J A Dunstan, D Martino, S McCarthy, J Metcalfe, M K Tulic, A Mori and S L Prescott. Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. Pediatrics. 2012 130 (4)pp.674