Dr Don Newgreen
Dr Don Newgreen obtained his PhD at the University of Melbourne's Zoology Department and has held postdoctoral research positions at the Institute d'Embryologie et Biologie Moleculaire (Paris, France), the Max Planck Institute for Developmental Biology (Tübingen, Germany), Department of Cell and Structural Biology, Manchester University (UK) and Department of Paediatric Surgery, Westmead Hospital (Sydney).
Dr Newgreen has served as a National Health and Medical Research Council (NHMRC) panel member and regularly assesses grant and fellowship applications from the NHMRC, Australian Research Council (ARC), as well as for granting bodies from USA, Canada, NZ, Hong Kong, Europe and UK. He regularly reviews for journals including Nature, J. Cell Biology, Stem Cells, Cancer Research, Cold Spring Harbor Protocols and many developmental journals. He is on the editorial board of Cells Tissues Organs, Development Growth & Differentiation, and Autonomic Neuroscience: Basic and Clinical and Frontiers in Autonomic Neuroscience.
Dr Newgreen initiated and was inaugural President of The EMT International Association (TEMTIA), dedicated to the process of cell separation and invasion known as epithelial-mesenchymalcell transition or EMT. He organises the highly successful biannual interdisciplinary TEMTIA conferences, which started in 2003. He was an inaugural member of the ARC Network in Genes and Environment in Development, the EMP athy Breast Cancer Network and the Asia-Pacific Network for Developmental Biology.
Dr Newgreen's major research interest throughout his career has been cell movement, particularly in the embryonic neural crest system, and how errors of cell movement lead to birth defects. This has also led to interests in invasive cancers, especially breast cancer, since the molecular underpinnings of cancer invasion involve the molecular genetic “hijacking" of normal embryonic cell migration programs. He uses techniques from classical experimental cell and developmental biology, to molecular biology and mathematical modelling. This has produced new understandings of the way cell movement is started by the process called the Epithelial-Mesenchymal Transition (EMT), and how it is guided and terminated in development and in cancer. He has identified fundamental errors leading to the neural crest birth defect Hirschsprung Disease. He is also actively investigating neural crest stem/progenitor cell therapies as a potential treatment for this disease. This research is currently being undertaken in animal and human cell and tissue models.
- Formation of human neural crest stem/progenitor cells from human iPS cells and human ES cells.
- Use of human neural crest stem/progenitor cells as a novel cell therapy for the neurocristopathy, Hirschsprung Disease.
- Molecular control of the formation of the enteric nervous system from neural crest cells
- Mathematical modelling of the formation of the enteric nervous system from neural crest cells
Cheeseman BL, Zhang DC, Binder BJ, Newgreen DF, Landman KA (2014) Cell lineage tracing in the developing enteric nervous system: superstars revealed by experiment and simulation. J. Roy. Soc. Interface 11: 20130815.
Xu B, Rollo B, Stamp LA, Zhang D, Fang X, Newgreen DF, Chen Q (2013). Non-linear elasticity of core/shell spun PGS/PLLA fibres and their effect on cell proliferation. Biomaterials 34, 6306-6317
Hotta R, Stamp LA, Foong J, McConnell SN, Bergner AJ, Anderson RB, Enomoto H, Newgreen DF, Obermayr F, Furness JB, Young HM (2013) Transplanted progenitors generate functional enteric neurons in the postnatal colon. J Clin Investig. 123:1182–1191.
Newgreen DF, Dufour S, Howard M, Landman KA (2013) Simple rules for a "simple" nervous system? Molecular and biomathematical approaches to enteric nervous system formation and malformation. Dev Biol. 382, 305-319.
Hugo HJ, Pereira L, Suryadinata R, Drabsch Y, Gonda TJ, Gunasinghe D, Pinto C, Soo ETL, van Denderen B, Hill P, Ramsay RG, Sarcevic B, Newgreen DF, Thompson EW (2013) Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells. Breast Cancer Research. 15, R113
Nishiyama C, Uesaka T, Manabe T, Yonekura Y, Nagasawa T, Milbrandt J., Newgreen DF, Young HM, Enomoto H. (2012) Trans-mesenteric neural crest cells are the principal source for the colonic enteric nervous system. Nature Neuroscience 15: 2011-2018.
Hackett-Jones EJ, Landman KA, Newgreen DF, Zhang DC (2011) On the role of differential adhesion in gangliogenesis in the enteric nervous system. J Theor Biol 287: 148–159.
Landman KA, Fernando AE, Zhang D, Newgreen DF.(2011) Building stable chains with motile agents: Insights into the morphology of enteric neural crest cell migration. J Theor Biol.; 276(1): 250-268.
Zhang DC, Brinas IM, Binder, B, Landman, KA and Newgreen DF (2010) Neural Crest Regionalisation for Enteric Nervous System Formation: Implications for Hirschsprung's Disease and Stem Cell Therapy. Dev Biol 339: 280-294.
Hotta R, Anderson RB., Kobayashi K, Newgreen DF, Young HM, (2010) Effects of tissue age, presence of neurones and endothelin-3 on the ability of enteric neurone precursors to colonize recipient gut: