Dr Gabrielle Wilson
Gabrielle Wilson completed her BSc (Hons) at the University of Melbourne and subsequently worked as a research assistant at Monash Medical Centre before joining the Bruce Lefroy Centre in 2004.
In 2006 Gabrielle was awarded a National Health and Medical Research Council (NHMRC) Dora Lush Biomedical Research scholarship to undertake her PhD investigating the genetic and molecular pathways underlying male infertility. While undertaking her PhD Gabrielle received several national and international awards, including the Society for Reproductive Biology New Investigator Award. Following the completion of her PhD in 2009, Gabrielle was awarded a NHMRC grant to continue research into proteins involved in ciliary disease.
Gabrielle has recently expanded her research by joining the Accelerated Gene Identification Program (AGIP) which aims to identify and characterise disease-causing genes underlying rare genetic disorders. As part of AGIP, Gabrielle's research focuses on neurodegenerative disorders including Parkinson's Disease and is supported by Parkinson's Disease Foundation funding.
- Honorary Research Fellow, The Department of Paediatrics, The University of Melbourne
- Graduate Researcher Degrees Committee, The Department of Paediatrics, The University of Melbourne
- Early-Mid Career Researcher Association (EMCRA), MCRI
- 2016-2017: Parkinson’s & Movement Disorder Foundation grant
- 2011-2013: Project Grant , NHMRC (CIB)
- 2007-2010: Commercialisation Training Scheme Scholarship, Commonwealth Government
- 2006-2009: Dora Lush Biomedical Research Scholarship, NHMRC,
- 2008: New Investigator Award, Society for Reproductive Biology
- 2008: Travelling Fellowship, Harold Mitchell Foundation
Parkinson's Disease is a neurodegenerative disease affecting a significant number of Australians. Currently 1 in 25 Australians are newly diagnosed with Parkinson's Disease each day and this number is expected to increase with the aging population. Despite the prevalence of disease the underlying genetic aetiology is unknown in the majority of cases.
Similarly, ciliary diseases including infertility and hydrocephalus display a clear genetic origin, however, the pathways governing ciliary formation, structure and function remain to be clearly established.
Therefore, Gabrielle's broad research focus is on gene discovery, with a particular interest in understanding the genetic and molecular pathways contributing to both ciliary disease and Parkinson's Disease.
This research utilises modern genomic and bioinformatics technologies in the gene discovery process. Subsequently, in vitro and in vivo models are utilised to delineate the pathways and mechanisms contributing to the healthy and disease states. The identification of genetic variation and downstream pathways responsible for disease will be beneficial to individuals and families in terms of diagnosis, family planning and also for potential targeted treatments.
- Accelerated Gene Identification Program (AGIP)
- Characterisation of novel cilia proteins and roles in human disease
- Identification and characterisation of a novel genes involved in neurodegenerative disease
Wilson, G.R., Sim, J.C., McLean, C., Giannandrea, M., Galea, C.A., Riseley, J.R., Stephenson, S.E., Fitzpatrick, E., Haas, S.A., Pope, K., Hogan, K.J., Gregg, R.G., Bromhead, C.J., Wargowski, D.S., Lawrence, C.H., James, P.A., Churchyard, A., Gao, Y., Phelan, D.G., Gillies, G., Salce, N., Stanford, L., Marsh, A.P., Mignogna, M.L., Hayflick, S.J., Leventer, R.J., Delatycki, M.B., Mellick, G.D., Kalscheuer, V.M., D'Adamo, P., Bahlo, M., Amor, D.J., Lockhart, P.J. (2014). Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with a-Synuclein Pathology. Am J Hum Genet. 95(6):729-35
Sim, J. C., White, S. M., Fitzpatrick, E., Wilson, G. R., Gillies, G., Pope, K., Mountford, H. S., Torring, P. M., McKee, S., Vulto-van Silfhout, A. T., Jhangiani, S. M., Muzny, D. M., Leventer, R. J., Delatycki, M. B., Amor, D. J., Lockhart, P. J. (2014). Expanding the phenotypic spectrum of ARID1B-mediated disorders and identification of altered cell-cycle dynamics due to ARID1B haploinsufficiency. Orphanet journal of rare diseases 9, 43-50
Wilson, G. R., Sunley, J., Smith, K. R., Pope, K., Bromhead, C. J., Fitzpatrick, E., Di Rocco, M., van Steensel, M., Coman, D. J., Leventer, R. J., Delatycki, M. B., Amor, D. J., Bahlo, M. & Lockhart, P. J. (2013). Mutations in SH3PXD2B cause Borrone dermato-cardio-skeletal syndrome. Eur J Hum Genet. 22, 741-747
Phelan, D., Wilson, G.R., James, P.A., Lockhart, P.J. (2013). The genetics of cardiomyopathy, new technologies and the path to personalised medicine . OA Genetics. 1, 9-19
Delatycki, M. B., Wolthuizen, M., Collins, V., Varley, E., Craven, J., Allen, K. J., Gurrin, L. C., Aitken, M., Trembath, M. K., Bond, L., Wilson, G. R., Stephenson, S. E., Macciocca, I., Hickerton, C., Lockhart, P. J. & Metcalfe, S. A. (2012). IronXS: high-school screening for hereditary haemochromatosis is acceptable and feasible. Eur J Hum Genet 20, 505-9
Wilson, G. R., Wang, H. X., Egan, G. F., Robinson, P. J., Delatycki, M. B., O'Bryan, M. K. & Lockhart, P. J. (2010). Deletion of the Parkin co-regulated gene causes defects in ependymal ciliary motility and hydrocephalus in the quakingviable mutant mouse. Hum Mol Genet 19, 1593-1602
Wilson, G. R., Sim, M. L., Brody, K. M., Taylor, J. M., McLachlan, R. I., O'Bryan, M. K., Delatycki, M. B. & Lockhart, P. J. (2009). Molecular analysis of the PArkin co-regulated gene and association with male infertility. Fertil Steril 93, 2262-2268
Wilson, G. R., Tan, J. T., Brody, K. M., Taylor, J. M., Delatycki, M. B. & Lockhart, P. J. (2009). Expression and localization of the Parkin co-regulated gene in mouse CNS suggests a role in ependymal cilia function. Neurosci Lett 460, 97-101
Delatycki, M., Wolthuizen, M., Collins, V., Varley, E., Craven, J., Allen, K., Aitken, M., Bond, L., Lockhart, P., Wilson, G., Macciocca, I. & Metcalfe, S. (2009). Implementation of ironXS: a study of the acceptability and feasibility of genetic screening for hereditary hemochromatosis in high schools. Clin Genet 77, 241-248.
- Parkinson’s & Movement Disorder Foundation grant
- Parkinson's Disease Foundation