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Dr Grant Mackenzie
Dr Grant Mackenzie is an epidemiologist/paediatrician with a particular interest in pneumococcal disease and vaccines, pneumonia and severe bacterial infections. He trained at the Royal Children's Hospital in Melbourne. His PhD at Menzies School of Health Research in Darwin described the effectiveness of pneumococcal conjugate vaccine in northern Australia. His Master of Public Health studies focussed on Aboriginal health, epidemiology and statistics.
Dr Mackenzie then spent two years with a paediatric HIV programme in Nairobi, Kenya, seconded from the University of Sydney. He has been based at the Medical Research Council (UK) unit in The Gambia since 2008 and is now seconded there from Murdoch Childrens. Dr Mackenzie has an Honorary appointment with the London School of Hygiene & Tropical Medicine.
Dr Mackenzie has been a Clinical Epidemiologist at the Basse Field Station of MRC (UK) The Gambia, since 2008. His research falls under the Maternal-Neonatal-Child Health Theme. He co-ordinates surveillance for pneumococcal disease and carriage in eastern Gambia, evaluating the effectiveness of the introduction of pneumococcal conjugate vaccine to reduce rates of invasive disease, radiologic pneumonia, carriage, and the cost-effectiveness of vaccination.
Dr Mackenzie is also involved in studies evaluating different pneumococcal vaccine schedules, documenting short and long-term outcomes after childhood pneumonia, socio-economic risk factors for pneumonia, evaluating IMCI criteria for pneumonia, and describing the epidemiology of pneumonia and the causes of serious bacterial illness.
- Pneumococcal Surveillance Project to measure the impact of the introduction of pneumococcal conjugate vaccine in The Gambia. Conducted in collaboration with the Gambian Ministry of Health. Led by Dr Mackenzie – funded by the Bill and Melinda Gates Foundation
- Hib surveillance for disease and carriage. Conducted in collaboration with the Gambian Ministry of Health. Dr Mackenzie is a co-investigator – funded by the GAVI Alliance
Grant A Mackenzie, Christian Bottomley, Albert J van Hoek, David Jeffries, Martin Ota, Syed MA Zaman, Brian Greenwood, Felicity Cutts. Efficacy of different pneumococcal conjugate vaccine schedules against pneumonia, hospitalisation, and mortality: re-analysis of a randomised trial in The Gambia. Vaccine. 2014;32(21),2493-2500. doi: 10.1016/j.vaccine.2014.02.081
E Usef, G Mackenzie, Y Lowe-Jallow, B Boye, D Atherly, C Suraratdecha, UK Griffiths. Costs of vaccine delivery in The Gambia before and after pentavalent and pneumococcal conjugate vaccine introductions. Vaccine. 2014;88(9):1975-81. doi: 10.1016/j.vaccine.2014.01.045
J Hossain, A Roca, G Mackenzie, M Jasseh, MI Hossain, S Muhammad, A Manjang, CD Osuorah, M Ndiaye, BS Muhammad, ON Ikumapayi, B Jeng, B Njie, M Cham, B Kampmann, T Corrah, S Howie, U D'Alessandro. Serogroup W135 Meningococcal Disease, The Gambia, 2012. Emerg Inf Dis. 2013;19(9),1507-1510. doi 10.3201/eid1909.130077
Nair H, Simoes EA, Rudan I, Gessner BD, Assiz-Baumgartner E, Zhang JSF, Feikin DR, Mackenzie GA, Moisi JC, Roca A, Baggett HC, Zaman SMA, Singleton RJ, Lucero MG, Chandran A, Gentile A, Cohen C, Krishnan A, Bhutta ZA, Arguedas A, Clara AW, Andrade AL, Ope M, Ruvinsky RO, Hortal M, McCracken JP, Madhi SA, Bruce N, Qasi SA, Morris SS, El Arifeen S, Weber MW, Scott JAG, Brooks WA, Breiman RF, Campbell H, et al. Global and regional burden of hospital admissions from severe acute lower respiratory infections in young children in 2010: a systematic analysis. Lancet. 2013;381(9864):1380-90. doi: 10.1016/S0140-6736(12)61901-1
Grant Mackenzie, Ian Plumb, Sana Sambou, Debasish Saha, Uchendu Uchendu, Bolanle Akinsola, Usman N Ikumapayi, Ignatius Baldeh, Effua Usuf, Kebba Touray, Momodou Jasseh, Stephen R Howie, Andre Wattiaux, Ellen Lee, Maria Deloria Knoll, Orin S Levine, Brian M Greenwood, Richard A Adegbola, Philip C Hill. Monitoring the Introduction of Pneumococcal Conjugate Vaccines into West Africa: Design and Implementation of a Population-Based Surveillance System. PLoS Med. 2012;9(1):e1001161
Mackenzie G, Leach A, Carapetis J, Fisher J, Morris P. Epidemiology of nasopharyngeal carriage of respiratory bacterial pathogens in children and adults: cross-sectional surveys in a population with high rates of pneumococcal disease. BMC Inf Dis. 2010;10:304
Mackenzie G, Ceesay SJ, Hill PC, Walther M, Bojang KA, Satoguina J, Enwere G, D'Alessandro U, Saha D, Ikumapayi UN, O'Dempsey T, Mabey DC, Corrah T, Conway DJ, Adegbola RA, Greenwood BM. A decline in the incidence of non-typhoidal Salmonella infection in The Gambia temporarily associated with a decline in malaria infection. PLoS ONE. 2010;5(5):e10568
Meehan AM, Mackenzie G, Shingadia D, Booy R. Protecting children with HIV against pneumococcal disease. Lancet ID. 2009; 9(7):394-5
Mackenzie G, Carapetis J, Leach A, Morris P. Pneumococcal vaccination and otitis media in Australian Aboriginal infants: comparison of two birth cohorts before and after introduction of vaccination. BMC Paed. 2009; 19(9):14
Hossain MJ, Saha D, Antonio M, Nasrin D, Blackwelder WC, Ikumapayi UN, Mackenzie GA, Adeyemi M, Jasseh M, Adegbola RA, Roose AW, Kotloff KL, Levine MM. Cryptosporidium infection in rural gambian children: Epidemiology and risk factors. PLoS Negl Trop Dis. 2019;13(7):e0007607.
Pneumonia Etiology Research for Child Health (PERCH) Study Group. Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study. Lancet. 2019 Jun 27. pii: S0140-6736(19)30721-4.
Respiratory syncytial, parainfluenza and influenza virus infection in young children with acute lower respiratory infection in rural Gambia. Mackenzie G.A., Vilane A., Salaudeen R., Hogerwerf L., van den Brink S., Wijsman L.A., Overduin P., Janssens T.K.S., de Silva T.I., van der Sande M.A.B., Kampmann B., Meijer A. Sci Rep. 2019 Nov 29;9(1):17965. doi: 10.1038/s41598-019-54059-4.