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Dr Heather Stanton
Dr Heather Stanton is a Post-Doctoral Research Fellow with experience in metalloproteinase research. She studied for her PhD at Strangeways Research Laboratory in Cambridge, UK, focussing on activation of the matrix metalloproteinases.
Dr Stanton returned to Australia in 1998 to join Amanda Fosang's group at the Department of Paediatrics, University of Melbourne, where she has developed expertise in cartilage biology and an interest in the ADAMTS metalloproteinases.
She became an Honorary Fellow with the Murdoch Childrens Research Institute at its inception in 2000 and currently works part-time with dual roles in research and research administration.
- Administrative Assistant, Department of Paediatrics, University of Melbourne
- 2010: Project Grant, Lynn Quayle Charitable Fund
- 2005- 2007: Project Grant, NHMRC
- 2004: Project Grant, Murdoch Childrens Research Institute
- 1999- 2003: Peter Doherty Postdoctoral Fellowship, NHMRC
- 1998: McGill Domestic Fellowship, Arthritis Australia
Dr Heather Stanton's work has focussed on the roles of the matrix metalloproteinases and aggrecanases (ADAMTS metalloproteinases) in the breakdown on cartilage in arthritis. She has studied the regulation and activity of these enzymes in cartilage and has followed the patterns of aggrecan fragmentation, in vitro and in vivo. She has a longstanding interest in the bioactivity of various cartilage matrix fragments. Her career highlight was the publication in Nature (2005) showing that ADAMTS-5 is the major aggrecanase in the mouse.
- How aggrecanases contribute to cartilage destruction
Stanton, H., Rogerson, FM., East, CJ., Golub, SB., Lawlor, KE., Meeker, CT, Little, CB., Last, K., Farmer, PJ., Campbell, IK., Fourie, AM., & Fosang, AJ. (2005) ADAMTS-5 is the major aggrecanase in mouse cartilage, in vivo and in vitro. Nature 434, 648-652
Fosang, AJ., Last, K., Stanton, H., Golub, SB., Little, CB., Brown, L., & Jackson, DC. (2010) Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan, in Matrix Metalloproteinase Protocols, Methods Mol Biol. 622 (Eds. IM. Clark, DA. Young, AD. Rowan), Humana Press, pp 622:312-347
Stanton, H., Golub, SB., Rogerson, FM., Last, K., Little, CB., Fosang, AJ. (2011) Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage. Nature Protocols 6, 388-404
Stanton, H., Melrose, J., Little, CB. & Fosang AJ. (2011) Proteoglycan degradation by the ADAMTS family of proteinases. Biochim. Biophys. Acta 1812, 1616-1629