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Dr Katrina Bell
Dr Katrina Bell currently works as a postdoctoral researcher in the Bioinformatics group, focusing on expression analysis (next generation sequencing and Microarray analysis). Previously Dr Bell headed the Murdoch Childrens Research Institute Bioinformatics group , which focused on collaborative analysis of expression and methylation data from the Institute's laboratory research groups. Dr Bell obtained her PhD from the University of Melbourne, Department of Paediatrics.
Dr Bell's main interest is in gene expression (RNA-sequencing and microarrays) and genomic analyses, with a particular focus on differential isoform expression. A gene is capable of producing many different versions of itself, which are referred to as isoforms. These isoforms may have very different biological functions and therefore are of great interest in understanding the molecular bases of development /disease. Dr Bell also has a strong interest in developmental biology and personalized medicine.
Bateman JF, Rowley L, Belluoccio D, Chan B, Bell K, Fosang AJ, Little CB. Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction. Arthritis Rheum. 2013 Jun;65(6):1547-60. doi: 10.1002/art.37900. PubMed PMID: 23436205
Wong NC, Ashley D, Chatterton Z, Parkinson-Bates M, Ng HK, Halemba MS, Kowalczyk A, Bedo J, Wang Q, Bell K, Algar E, Craig JM, Saffery R. A distinct DNA methylation signature defines pediatric pre-B cell acute lymphoblastic leukemia. Epigenetics. 2012 Jun 1;7(6):535-41
Howlett M, Chalinor HV, Buzzelli JN, Nguyen N, van Driel IR, Bell KM, Fox JG, Dimitriadis E, Menheniott TR, Giraud AS, Judd LM. IL-11 is a parietal cell cytokine that induces atrophic gastritis. Gut. 2012 Oct;61(10):1398-409. doi: 10.1136/gutjnl-2011-300539. Epub 2011 Dec 16. PubMed PMID: 22180059; PubMed Central PMCID: PMC3471558
Cameron TL, Bell KM, Tatarczuch L, Mackie EJ, Rajpar MH, McDermott BT, Boot-Handford RP, Bateman JF. Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy. PLoS One. 2011;6(9):e24600. doi: 10.1371/journal.pone.0024600. Epub 2011 Sep 15. PubMed PMID: 21935428; PubMed Central PMCID: PMC3174197
White S, Ohnesorg T, Notini A, Roeszler K, Hewitt J, Daggag H, Smith C, Turbitt E, Gustin S, van den Bergen J, Miles D, Western P, Arboleda V, Schumacher V, Gordon L, Bell K, Bengtsson H, Speed T, Hutson J, Warne G, Harley V, Koopman P, Vilain E, Sinclair A. Copy number variation in patients with disorders of sex development due to 46,XY gonadal dysgenesis. PLoS One. 2011 Mar 7;6(3):e17793. doi: 10.1371/journal.pone.0017793. PubMed PMID: 21408189; PubMed Central PMCID: PMC3049794
Menheniott TR, Peterson AJ, O'Connor L, Lee KS, Kalantzis A, Kondova I, Bontrop RE, Bell KM, Giraud AS. A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans. Gastroenterology. 2010 May;138(5):1823-35. doi: 10.1053/j.gastro.2010.01.050. Epub 2010 Feb 4. PubMed PMID: 20138039