Dr Peter Farlie
Dr Peter Farlie trained in Biochemistry at La Trobe University and completed his PhD in developmental neurobiology at the Walter and Eliza Hall Institute. He continues to focus on developmental biology and in particular, the mechanisms regulating development and the way early development is coordinated between different parts of the embryo. These issues are particularly important in trying to understand the causes of birth defects. The Craniofacial Development Group investigates the mechanisms of normal craniofacial development and how these processes are altered to cause craniofacial defects. The group is also interested in the origins of birth defects generally, since many birth defect syndromes involve multiple organ systems.
Dr Farlie is also the deputy Director for Research in the Department of Plastic and Maxillofacial Surgery at the Royal Children's Hospital. He is on the Editorial Board of the journal, Genesis. His research group is committed to providing a dynamic learning environment and regularly has Honours and PhD students.
Dr Farlie's research focus and interests include developmental biology, embryonic patterning and organogenesis, the origins of birth defects, human genetics and craniofacial development.
- Understanding the causes of birth defects.
- A novel surveillance system that prevents human birth defects
Miller KA, Ah-Cann CJ, Welfare MF, Tan TY, Pope K, Caruana G, Freckmann M-L, Savarirayan R, Bertram JF, Dobbie MS, Bateman JF and Farlie PG. (2013) Cauli: a mouse strain with an Ift140 mutation that results in a skeletal ciliopathy modelling Jeune syndrome. PLoS Genetics 9(8):e1003746
Miller KA, Gordon CT, Welfare MF, Caruana G, Bertram JF, Bateman JF, Farlie PG.(2013) bfb, a novel ENU-induced blebs mutant resulting from a missense mutation in Fras1. PLoS ONE 8(10):e76342
Wade, C, Brinas, I, Wicking, C, Welfare, MF, Farlie, PG (2012). Twist2 mediates limb outgrowth and patterning through direct regulation of Grem1. Developmental Biology 370(1):145-53
Gordon CT. Brinas IML, Rodda FA, Bendall AJ and Farlie PG (2010). Role of Dlx genes in craniofacial morphogenesis: Dlx2 influences skeletal patterning by inducing ectomesenchymal aggregation in ovo. Evolution and Development 12(5):459-73.
Christopher T. Gordon, Tiong Yang Tan, Sabina Benko, David FitzPatrick, Stanislas Lyonnet and Peter G. Farlie (2009). Long-range regulation at the SOX9 locus in development and disease. J Med Genet 46:649-56.
Benko S, Fantes JA, Amiel J, Kleinjan DJ, Thomas S, Ramsay J, Jamshidi N, Essafi A, Heaney S, Gordon CT, McBride D, Golzio C, Fisher M, Perry P, Abadie V, Ayuso C, Holder-Espinasse M, Kilpatrick N, Lees MM, Picard A, Temple IK, Thomas P, Vazquez MP, Vekemans M, Crollius HR, Hastie ND, Munnich A, Etchevers HC, Pelet A, Farlie PG, Fitzpatrick DR, Lyonnet S. (2009). Highly conserved non-coding elements on either side of the SOX9 gene associated with Pierre Robin sequence . Nature Genetics 41(3):359-64.
Craig A. Smith, Kelly N. Roeszler, Thomas Ohnesorg, David M. Cummins, Peter G. Farlie , Timothy J Doran and Andrew H Sinclair (2009) The conserved avian Z-linked gene DMRT1 is required for male sex determination in the chicken embryo. Nature 461:267-71
McKeown, SJ, Lee, V, Bronner-Fraser, M Newgreen, DF. and Farlie, PG. (2005) Sox10 overexpression induces neural crest cells from all dorsoventral levels of the neural tube but inhibits differentiation. Dev Dynamics, 233:430-44
McKeown, SJ, Newgreen, DF. and Farlie, PG. (2005) Dlx2 over-expression regulates cell adhesion and mesenchymal condensation in ectomesenchyme. Dev Biol 281:22-37.
Farlie, P.G., Kerr, R., Thomas, P., Symes, T., Minichiello, J., Hearn, C.J. and Newgreen, D. (1999). A paraxial exclusion zone creates patterned cranial neural crest outgrowth adjacent to rhombomeres 3 and 5. Dev. Biol. 213, 70-84.