Dr Stephen Leslie
Dr Stephen Leslie is a statistician working in the field of mathematical genetics. He obtained his doctorate from the Department of Statistics, University of Oxford in 2008, under the supervision of Professor Peter Donnelly FRS. After graduating, Dr Leslie took up a position as a postdoctoral researcher in the Department of Statistics at Oxford.
He was then awarded one of the prestigious Nuffield Department of Medicine Scientific Leadership Fellowships to work on HIV and other pathogens. In late 2010, Dr Leslie was recruited by Sir Walter Bodmer FRS and Peter Donnelly to lead the statistical analyses for the People of the British Isles Project, a major UK research project investigating fine-scale genetic differences across the British Isles, including the consequences and causes of any observed differences.
In February 2012, Dr Leslie returned to Australia to establish his own research group at the Murdoch Childrens Research Institute as the Group Leader in Statistical Genetics. He also holds a National Health and Medical Research Council (NHMRC) Career Development Fellowship.
- Honorary Fellow, Department of Mathematics and Statistics, The University of Melbourne
- Teaching Excellence Award, University of Oxford, 2008
- Scientific Leadership Fellowship, Nuffield Department of Medicine, University of Oxford, 2010
- Career Development Fellowship, National Health and Medical Research Council, 2013
Dr Leslie's work covers several aspects of statistical and population genetics. His main interests are in both applying mainstream statistical developments to genetics, and in developing new statistical methods motivated by problems arising in genetics. In particular, Dr Leslie works on developing statistical methods for the analysis of modern genetic and genomic data sets, with a particular focus on understanding the role of genetics in human diseases.
Within this broad field he has two main interests. The first is developing statistical methods to type immune system genes (e.g. HLA) using SNP and other data. This enables high-throughput, accurate and inexpensive typing of the alleles of these genes, meaning that these can be incorporated in large cohort studies to understand the role of HLA and other genes in disease susceptibility. In this context he is also interested in methods for incorporating imputed alleles into disease studies, properly accounting for uncertainty in imputation. The second interest is in detecting and understanding population structure, and accounting for this in studies of disease and other phenotypes. A key aspect of his work is providing software tools for other researchers to use.
Stephen Leslie*, Bruce Winney*, Garrett Hellenthal*, Dan Davison, Abdelhamid Boumertit, Tammy Day, Katarina Hutnik, Ellen C Royrvik, Barry Cunliffe, Wellcome Trust Case Control Consortium 2, International Multiple Sclerosis Genetics Consortium, Daniel J Lawson, Daniel Falush, Colin Freeman, Matti Pirinen, Simon Myers, Mark Robinson, Peter Donnelly and Walter Bodmer. The fine scale genetic structure of the British population, Nature, 519: 309-314, 2015. *contributed equally. doi:10.1038/nature14230
Philippe Goyette, Gabrielle Boucher, Dermot Mallon, Eva Ellinghaus, Luke Jostins, Hailiang Huang, Stephan Ripke, Elena Gusareva, Vito Annese, Stephen L. Hauser, Jorge R. Oksenberg, Ingo Thomsen, Stephen Leslie, International IBD Genetics Consortium, Mark J. Daly, Kristel van Steen, Richard H. Duerr, Jeff Barrett, Dermot McGovern, Phil Schumm, James A. Traherne, Mary N. Carrington, Vasilis Kosmoliaptsis, Tom H. Karlsen, Andre Franke, John D. Rioux. High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis, Nature Genetics, 47: 172–179, 2015, doi:10.1038/ng.3176.
Marc Turner, Stephen Leslie, Nick Martin, Marc Peschanski, Mahendra Rao, Craig J.Taylor, David Turner, Shinya Yamanaka, Ian Wilmut. Towards the development of a global induced pluripotent stem cell haplobank, Cell Stem Cell, 13 (4): 382-384, 2013.
Alexander Dilthey*, Stephen Leslie*, Loukas Moutsianas, Judong Shen, Charles Cox, Matthew R. Nelson, Gil McVean. Multi-Population Classical HLA Type Imputation,PLoS Computational Biology, 9 (2): e1002877, 2013 *contributed equally.
Benjamin P. Fairfax, Seiko Makino, Jayachandran Radhakrishnan, Katherine Plant, Stephen Leslie, Alexander Dilthey, Peter Ellis, Cordelia Langford, Fredrik O. Vannberg, Adrian V. S. Hill, Julian C. Knight. Analysis of positively selected primary B-cells and monocytes reveals cell-specific master regulatory regions involving LYZ, KLF4 and HLA alleles with implications for autoimmune and inflammatory disease, Nature Genetics, 44 (5): 502 – 510, 2012.
The International Multiple Sclerosis Genetics Consortium (IMSGC) and the Wellcome Trust Case Control Consortium 2 (WTCCC2). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis, Nature, 476 (7359): 214 – 219, 2011.
Australo-Anglo-American Spondyloarthritis Consortium (TASC) and the Wellcome Trust Case Control Consortium 2 (WTCCC2). Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility, Nature Genetics, 43 (8): 761–767, 2011.
The Genetic Analysis of Psoriasis (GAP) Consortium and the Wellcome Trust Case Control Consortium 2 (WTCCC2). A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1, Nature Genetics, 42 (11): 985 – 990, 2010.
The International HapMap Consortium. Integrating common and rare genetic variation in diverse human populations, Nature, 467 (7311): 52 – 58, 2010.
Stephen Leslie, Peter Donnelly and Gil McVean. A statistical method for predicting classical HLA alleles from SNP data, American Journal of Human Genetics, 82 (1):48 – 56, 2008.